Evidence map›Paper›PMID 25540947›Full record

ArticleJournal of neurogastroenterology and motility2015

Brain-based Correlations Between Psychological Factors and Functional Dyspepsia.

Jiaofen Nan, Jixin Liu, Junya Mu, Wanghuan Dun, Ming Zhang, Qiyong Gong, Wei Qin, Jie Tian, Fanrong Liang, Fang Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurogastroenterology and motility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis.Progress in neuro-psychopharmacology & biological psychiatry · 2021
    Review
  12. Article
  13. Beneficial Potential ofFrontiers in pharmacology · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Sex and Gender Differences in Gastroesophageal Reflux Disease.Journal of neurogastroenterology and motility · 2016
    Review
  20. Functional dyspepsia: new insights into pathogenesis and therapy.The Korean journal of internal medicine · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiaofen NanSchool of Life Science and Technology, Xidian University, Xi'an, China.
Jixin LiuSchool of Life Science and Technology, Xidian University, Xi'an, China.
Junya MuSchool of Life Science and Technology, Xidian University, Xi'an, China.
Wanghuan DunDepartment of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Ming ZhangDepartment of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Qiyong GongDepartment of Radiology, The Center for Medical Imaging, Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Wei QinSchool of Life Science and Technology, Xidian University, Xi'an, China.
Jie TianSchool of Life Science and Technology, Xidian University, Xi'an, China.
Fanrong LiangThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Fang ZengThe 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsIncreasing evidence shows involvement of psychological disorders in functional dyspepsia (FD), but how psychological factors exert their influences upon FD remains largely unclear. The purpose of the present study was to explore the brain-based correlations of psychological factors and FD.

methodsBased on Fluorine-18-deoxyglucose positron emission tomography-computed tomography, the altered cerebral glycometabolism was investigated in 40 FD patients compared with 20 healthy controls during resting state using statistical parametric mapping software.

resultsFD patients exhibited increased glucose metabolism in multiple regions relative to controls (P< 0.001, family-wise error corrected). After controlling for the dyspeptic symptoms, increased aberrations persisted within the insula, anterior cingulate cortex (ACC), middle cingulate cortex (MCC) and middle frontal cortex (midFC), which was related to anxiety and depression score. Interestingly, FD patients without anxiety/depression symptoms also showed increased glycometabolism within the insula, ACC, MCC and midFC. Moreover, FD patients with anxiety/depression symptoms exhibited more significant hypermetabolism within the above 4 sites compared with patients without anxiety/depression symptoms.

conclusionsOur results suggested that the altered cerebral glycometabolism may be in a vicious cycle of psychological vulnerabilities and increased gastrointestinal symptoms.

Indexed as

Cerebral cortexDyspepsiaGlucose

Identifiers

PMID25540947
PMCPMC4288085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.