Evidence map›Paper›PMID 25540931›Full record

ArticlePhysiology & behavior2015

Parabrachial lesions in rats disrupt sodium appetite induced by furosemide but not by calcium deprivation.

P S Grigson, E M Colechio, M L Power, J Schulkin, R Norgren

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Parabrachial Complex: A Hub for Pain and Aversion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

P S GrigsonDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA. Electronic address: psg6@psu.edu.
E M ColechioDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA. Electronic address: emc231@psu.edu.
M L PowerNutrition Laboratory and Conservation Ecology Center, Smithsonian Conservation Biology Institute, National Zoological Park, P. O. Box 37012, MRC 5503, Washington, DC 20013-7012, USA. Electronic address: mpower@acog.org.
J SchulkinDepartment of Neuroscience, Basic Sciences Building, Georgetown University, 3900 Reservoir Road, N.W., Washington, DC 20057, USA. Electronic address: Jschulkin@acog.org.
R NorgrenDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA. Electronic address: rxn5@psu.edu.
Pennsylvania State University · USGeorgetown University · USSmithsonian Conservation Biology Institute · US

Funding

NEURAL SYSTEMS OF INGESTIVE BEHAVIORR01DC000240 · NIDCD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HAJNAL, ANDRAS · 1989 to 2014
$5.1M
Gustatory Control of Sodium AppetiteR01DC005435 · NIDCD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI NORGREN, RALPH · 2002 to 2012
$3.2M
Drugs of Abuse and Learned Aversions: Solving a ParadoxR37DA009815 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GRIGSON, PATRICIA SUE · 2012 to 2020
$2.9M
DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUSR01DA012473 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GRIGSON, PATRICIA SUE · 2000 to 2010
$2.9M
DRUGS OF ABUSE AND LEARNED AVERSIONS: SOLVING A PARADOXR01DA009815 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GRIGSON, PATRICIA SUE · 1996 to 2011
$2.3M
NIDA NIH HHS DA009815NIDA NIH HHS DA012473NIDA NIH HHS R01 DA009815NIDA NIH HHS R01 DA012473NIDA NIH HHS R37 DA009815NIDCD NIH HHS DC00240NIDCD NIH HHS DC05435NIDCD NIH HHS R01 DC000240NIDCD NIH HHS R01 DC005435
6 · The paper itself

Abstract

An appetite for CaCl2 and NaCl occurs in young rats after they are fed a diet lacking Ca or Na, respectively. Bilateral lesions of the parabrachial nuclei (PBN) disrupt normal taste aversion learning and essentially eliminate the expression of sodium appetite. Here we tested whether similar lesions of the PBN would disrupt the calcium-deprivation-induced appetite for CaCl2 or NaCl. Controls and rats with PBN lesions failed to exhibit a calcium-deprivation-induced appetite for CaCl2. Nevertheless, both groups did exhibit a significant calcium-deprivation-induced appetite for 0.5M NaCl. Thus, while damage to the second central gustatory relay in the PBN disrupts the appetite for 0.5M NaCl induced by furosemide, deoxycorticosterone acetate, and polyethylene glycol, the sodium appetite induced by dietary CaCl2 depletion remains intact.

Indexed as

Analysis of VarianceAnimalsAppetiteCalciumCalcium ChlorideConditioning, PsychologicalDesoxycorticosterone AcetateDisease Models, AnimalDiureticsExcitatory Amino Acid AgonistsFurosemideIbotenic AcidParabrachial NucleusPolyethylene GlycolsRatsRats, Sprague-DawleyCalciumCalcium ChlorideDesoxycorticosterone AcetateDiureticsExcitatory Amino Acid AgonistsFurosemideIbotenic AcidPolyethylene GlycolsSodium ChlorideCalcium depletionMineral appetiteParabrachialSodium depletion

Identifiers

PMID25540931
PMCPMC4477629
OpenAlexW2038892225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.