Evidence map›Paper›PMID 25540806›Full record

ArticleAnnals of clinical and translational neurology2014

Pediatric anti-NMDA receptor encephalitis is seasonal.

Laura A Adang, David R Lynch, Jessica A Panzer

Abstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Observational
  9. Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Encephalitis in Children and Adolescents: A Systematic Review and Quantitative Analysis of Reported Cases.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2021
    Article
  10. The Causes and Long-Term Consequences of Viral Encephalitis.Frontiers in cellular neuroscience · 2021
    Review
  11. Article
  12. Normal gut microbiome in NMDA receptor encephalitis.Neurology(R) neuroimmunology & neuroinflammation · 2019
    Article
  13. Review
  14. Mechanisms of Autoantibody-Induced Pathology.Frontiers in immunology · 2017
    Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Laura A AdangDepartments of Pediatrics and Neurology, University of Pennsylvania Philadelphia, Pennsylvania, 19104.
David R LynchDepartments of Pediatrics and Neurology, University of Pennsylvania Philadelphia, Pennsylvania, 19104 ; Departments of Pediatrics and Child Psychiatry, The Children's Hospital of Philadelphia, University of Pennsylvania Philadelphia, Pennsylvania, 19104 ; Perelman School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania, 19104.
Jessica A PanzerDepartments of Pediatrics and Neurology, University of Pennsylvania Philadelphia, Pennsylvania, 19104.

Funding

Training Program in Neurodevelopmental DisabilitiesT32NS007413 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI AMELIA J EISCH, ERIC D MARSH · 1998 to 2026
$8.9M
NSADA Training Grant for Child NeurologistsK12NS049453 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI TENNEKOON, GIHAN I · 2006 to 2015
$4.4M
Defining the epitope in anti-AMPA receptor encephalitisR21NS081439 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI LYNCH, DAVID ROBINSON · 2012 to 2013
$453k
NINDS NIH HHS K12 NS049453NINDS NIH HHS R21 NS081439NINDS NIH HHS T32 NS007413
6 · The paper itself

Abstract

In the majority of pediatric anti-N-methyl-d-aspartate receptor encephalitis (NMDARe) cases, the underlying cause of antibody production and subsequent disease remains unknown. We aimed to characterize this poorly understood population, investigating epidemiological factors potentially related to disease etiology, particularly season of onset. In this retrospective case review study, we analyzed data from the 29 pediatric subjects with anti-NMDAR antibodies and found that symptoms were first reported in the warm months of April-September in 78% of non-tumor-related NMDARe (NT-NMDARe) cases. These findings support further investigation into a possible seasonal trigger of NT-NMDARe.

Identifiers

PMID25540806
PMCPMC4265063

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.