Evidence map›Paper›PMID 25540681›Full record

ArticleBiology of mood & anxiety disorders2014

Brain white matter integrity and association with age at onset in pediatric obsessive-compulsive disorder.

Isabelle M Rosso, Elizabeth A Olson, Jennifer C Britton, S Evelyn Stewart, George Papadimitriou, William Ds Killgore, Nikos Makris, Sabine Wilhelm, Michael A Jenike, Scott L Rauch

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of mood & anxiety disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  16. Developmental Neuroimaging in Pediatric Obsessive-Compulsive Disorder.Current behavioral neuroscience reports · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Isabelle M RossoCenter for Depression, Anxiety and Stress Research, McLean Hospital, 115 Mill Street, mailstop 334, Belmont, MA 02478 USA ; Department of Psychiatry, Harvard Medical School, Boston, MA USA.
Elizabeth A OlsonCenter for Depression, Anxiety and Stress Research, McLean Hospital, 115 Mill Street, mailstop 334, Belmont, MA 02478 USA ; Department of Psychiatry, Harvard Medical School, Boston, MA USA.
Jennifer C BrittonDepartment of Psychology, University of Miami, 5665 Ponce de Leon Blvd, Flipse Building, Coral Gables, Miami, FL 33146 USA.
S Evelyn StewartBritish Columbia Mental Health and Addictions Research Institute, University of British Columbia, Vancouver, BC Canada ; UBC Psychiatry A3-118, 938 West 28th Ave, Vancouver, BC V5Z 4H4 Canada.
George PapadimitriouCenter for Morphometric Analysis, Massachusetts General Hospital, Bldg 149, 13th Street, Charlestown, MA 02129 USA ; Department of Neurology, Harvard Medical School, Boston, MA USA ; Department of Radiology, Harvard Medical School, Boston, MA USA.
William Ds KillgoreCenter for Depression, Anxiety and Stress Research, McLean Hospital, 115 Mill Street, mailstop 334, Belmont, MA 02478 USA ; Department of Psychiatry, Harvard Medical School, Boston, MA USA.
Nikos MakrisCenter for Morphometric Analysis, Massachusetts General Hospital, Bldg 149, 13th Street, Charlestown, MA 02129 USA ; Department of Neurology, Harvard Medical School, Boston, MA USA ; Department of Radiology, Harvard Medical School, Boston, MA USA.
Sabine WilhelmDepartment of Psychiatry, Harvard Medical School, Boston, MA USA ; Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, 185 Cambridge Street, Suite 2282, Boston, MA 02114 USA.
Michael A JenikeDepartment of Psychiatry, Harvard Medical School, Boston, MA USA ; Department of Psychiatry, Massachusetts General Hospital, Simches Research Building, 185 Cambridge Street, Suite 2282, Boston, MA 02114 USA ; Department of Psychiatry, University of Arizona, Tucson, AZ USA.
Scott L RauchCenter for Depression, Anxiety and Stress Research, McLean Hospital, 115 Mill Street, mailstop 334, Belmont, MA 02478 USA ; Department of Psychiatry, Harvard Medical School, Boston, MA USA.
Massachusetts General Hospital · USMcLean Hospital · USUniversity of British Columbia · CAUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObsessive-compulsive disorder (OCD) is a common and debilitating neuropsychiatric illness thought to involve abnormal connectivity of widespread brain networks, including frontal-striatal-thalamic circuits. At least half of OCD cases arise in childhood and their underlying neuropathology may differ at least in part from that of adult-onset OCD. Yet, only a few studies have examined brain white matter (WM) integrity in childhood-onset OCD using diffusion tensor imaging (DTI), and none have examined potential associations with age at onset.

resultsIn this study, 17 youth with OCD and 19 healthy control subjects, ages 10 to 19 years, underwent DTI on a 3T Siemens scanner. DSM-IV diagnoses were established with standardized interviews, and OCD symptom severity was evaluated using the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). Voxel-wise analyses were conducted on data processed with tract-based spatial statistics (TBSS) to derive measures of fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD). OCD patients had significantly lower FA in seven WM clusters, with over 80% of significant voxels in bilateral frontal cortex and corpus callosum (CC). There were no regions of significantly higher FA in patients compared with controls. Patients also had significantly higher RD in right frontal cortex and right body of the CC. Earlier age at onset of OCD correlated significantly with lower FA in the right thalamus and with higher RD in the right CC. FA and RD were not significantly associated with symptom severity.

conclusionsThese findings point to compromised WM integrity and reduced myelination in some brain regions of children with OCD, particularly the CC and fiber tracts that connect the frontal lobes to widespread cortical and subcortical targets. They also suggest that age at onset may be a moderator of some of the WM changes in pediatric OCD.

Indexed as

Age at onsetChildhoodCorpus callosumDiffusion tensor imagingObsessive-compulsive disorderThalamus

Identifiers

PMID25540681
PMCPMC4275938
OpenAlexW2096482083

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.