ArticleMolecular autism2014
Association study between autistic-like traits and polymorphisms in the autism candidate regions RELN, CNTNAP2, SHANK3, and CDH9/10.
Article in Molecular autism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Pooled it
- Unraveling folate deficiency: prevalence, biochemical associations, genetic determinants, and strategies for adolescent health in North India.European journal of clinical nutrition · 2025Article
- Low Plasma Levels of Contactin-Associated Protein-Like 2 in Children with Autism Spectrum Disorder: Links to Neural Development.Neuropsychiatric disease and treatment · 2024Article
- Gut Microbiota Ecology and Inferred Functions in Children With ASD Compared to Neurotypical Subjects.Frontiers in microbiology · 2022Article
- SHANK3 Genotype Mediates Speech and Language Phenotypes in a Nonclinical Population.Autism research and treatment · 2021Article
- Association between Genetic Variants inBehavioural neurology · 2021Article
- Integrative analyses indicate an association between ITIH3 polymorphisms with autism spectrum disorder.Scientific reports · 2020Article
- Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions.Nutrients · 2019Review
- Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder.Stem cells international · 2019Article
- Grand-maternal smoking in pregnancy and grandchild's autistic traits and diagnosed autism.Scientific reports · 2017Article
- Replicable in vivo physiological and behavioral phenotypes of theMolecular autism · 2017Article
- Effects of sex and gonadectomy on social investigation and social recognition in mice.BMC neuroscience · 2015Article
- 5p deletions: Current knowledge and future directions.American journal of medical genetics. Part C, Seminars in medical genetics · 2015Review
- Association of SHANK3 Gene Polymorphism and Parkinson Disease in the North of Iran.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutistic-like traits (ALTs) are continuously distributed in the general population, with the autism spectrum disorder (ASD) at the upper extreme end. A genetic overlap has been shown between ALTs and ASD, indicating that common variation in ASD candidate genes may also influence ALTs. In our study, we have investigated the SNP rs4307059 that has been associated with both ALTs and ASD. In addition, we genotyped polymorphisms in a selection of genes involved in synaptic functioning, that is, SHANK3, RELN, and CNTNAP2, which repeatedly have been associated with ASD. The possible associations of these polymorphisms with ALTs, as well as genetic factors for neurodevelopmental problems (NDPs), were investigated in a large cohort from the general population: The Child and Adolescent Twin Study in Sweden. For analyses of ALTs and NDPs, 12,319 subjects (including 2,268 monozygotic (MZ) and 3,805 dizygotic (DZ) twin pairs) and 8,671 subjects (including 2,243 MZ and 2,044 DZ twin pairs), respectively, were included in the analyses.
findingsWe could not replicate the previous association between rs4307059 and social communication impairment. Moreover, common variations in CNTNAP2 (rs7794745 and rs2710102), RELN (rs362691), and SHANK3 (rs9616915) were not significantly associated with ALTs in our study.
conclusionsOur results do not suggest that the investigated genes, which previously has been found associated with ASD diagnosis, have any major influence on ALTs in children from the general population.
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