Evidence map›Paper›PMID 25540672›Full record

ArticleDiabetology & metabolic syndrome2014

Serum prolidase activity is associated with non-diabetic metabolic syndrome.

Suzan Tabur, Elif Oguz, Mehmet Ali Eren, Hakan Korkmaz, Esen Savas, Nurten Aksoy, Tevfik Sabuncu

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03334968 (Serum Prolidase Enzyme Activity as a Diagnostic Marker for Acute Ischemic Stroke), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03334968 completednot on this mapstarted 2016, after this paper: background citation

Serum Prolidase Enzyme Activity as a Diagnostic Marker for Acute Ischemic Stroke

TypeobservationalSponsorBezmialem Vakif UniversityRan2016 to 2017Enrolled74ConditionsStroke, Ischemic, Prolidase Deficiency
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Prolidase Enzyme Activity in Conjunctiva and Pterygium Tissues.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Suzan TaburFaculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey.
Elif OguzFaculty of Medicine, Department of Medical Pharmacology, Harran University, 63300 Sanliurfa, Turkey.
Mehmet Ali ErenFaculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Harran University, 63300 Sanliurfa, Turkey.
Hakan KorkmazFaculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey.
Esen SavasFaculty of Medicine, Department of Internal Medicine, Gaziantep University, 27100 Sahinbey, Gaziantep Turkey.
Nurten AksoyFaculty of Medicine, Department of Clinical Biochemistry, Harran University, 63300 Sanliurfa, Turkey.
Tevfik SabuncuFaculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Harran University, 63300 Sanliurfa, Turkey.
Harran University · TRGaziantep University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to determine the role of serum prolidase activity and the possible association with oxidative stress parameters in non-diabetic metabolic syndrome.

methods30 obese patients without metabolic syndrome (MetS), 34 non-diabetic obese patients with MetS, and 23 volunteer control subjects were enrolled in the study. Fasting plasma glucose (FPG), plasma glucose following 75 g glucose administration, high-density lipoprotein- cholesterol (HDL-C), high-density lipoprotein- cholesterol (LDL-C), total cholesterol, triglyceride (TG), total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and prolidase activities of all subjects were analyzed.

resultsProlidase levels was significantly higher in MetS group compared to both obese and control groups (p < 0.001 and p < 0.05 respectively). Prolidase was also higher in the obese group than in the control group (p < 0.05). Prolidase was negatively correlated with TAS and HDL-C (r = -0,362, p < 0.001; r = -0.320, p < 0.01, respectively) and positively correlated with BMI, weight, waist-c, SBP, DBP, TG, TC, LDL-C.

conclusionProlidase activity may have a role in the pathogenesis of metabolic syndrome.

Indexed as

Metabolic syndromeNon-diabeticObesityProlidase

Identifiers

PMID25540672
PMCPMC4276100
OpenAlexW2149601651

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.