ReviewFrontiers in pharmacology2014
Alterations in function and expression of ABC transporters at blood-brain barrier under diabetes and the clinical significances.
Review in Frontiers in pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Liraglutide and denatonium benzoate attenuate T2DM-induced metabolic, neurological, and testicular changes in rats: Targeting oxidative stress, inflammation, and BCRP transporter.Journal of molecular histology · 2025Article
- The Crucial Role of the Blood-Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications.Journal of clinical medicine · 2025Review
- Review
- Alzheimer's disease brain endothelial-like cells reveal differential drug transporter expression and modulation by potentially therapeutic focused ultrasound.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Article
- Expression of ATP-binding cassette subfamily B member 1 gene in peripheral blood of patients with acute myocardial infarction.Bioengineered · 2022Article
- Age-Dependent Changes in the Plasma and Brain Pharmacokinetics of Amyloid-β Peptides and Insulin.Journal of Alzheimer's disease : JAD · 2022Article
- Impact of theInfection and drug resistance · 2022Article
- Current trends in drug metabolism and pharmacokinetics.Acta pharmaceutica Sinica. B · 2019Review
- Changes of Blood-Brain Barrier and Brain Parenchymal Protein Expression Levels of Mice under Different Insulin-Resistance Conditions Induced by High-Fat Diet.Pharmaceutical research · 2019Article
- Development of precision medicine approaches based on inter-individual variability of BCRP/Acta pharmaceutica Sinica. B · 2019Review
- Altered Function and Expression of ABC Transporters at the Blood-Brain Barrier and Increased Brain Distribution of Phenobarbital in Acute Liver Failure Mice.Frontiers in pharmacology · 2018Article
- Diabetes, adult neurogenesis and brain remodeling: New insights from rodent and zebrafish models.Neurogenesis (Austin, Tex.) · 2017Review
- Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity.European journal of drug metabolism and pharmacokinetics · 2016Review
- Impact of cigarette smoke extract and hyperglycemic conditions on blood-brain barrier endothelial cells.Fluids and barriers of the CNS · 2015Article
- Altered glycaemia differentially modulates efflux transporter expression and activity in hCMEC/D3 cell line.Neuroscience letters · 2015Article
- Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?Frontiers in neuroscience · 2015Review
- Can insulin signaling pathways be targeted to transport Aβ out of the brain?Frontiers in aging neuroscience · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes is a systematic metabolic disease, which often develops a number of well-recognized vascular complications including brain complications which may partly result from the dysfunction of blood-brain barrier (BBB). BBB is generally considered as a mechanism for protecting the brain from unwanted actions resulting from substances in the blood and maintaining brain homeostasis via monitoring the entry or efflux of compounds. ATP-binding cassette (ABC) family of transporters including P-glycoprotein (P-GP) and breast cancer-related protein (BCRP), widely expressed in the luminal membrane of the microvessel endothelium and in the apical membrane of the choroids plexus epithelium, play important roles in the function of BBB. However, these transporters are easily altered by some diseases. The present article was focused on the alteration in expression and function of both P-GP and BCRP at BBB by diabetes and the clinical significances.
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