ArticleFrontiers in systems neuroscience2014
Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity.
Article in Frontiers in systems neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Anesthetic action on the transmission delay between cortex and thalamus explains the beta-buzz observed under propofol anesthesia.PloS one · 2017Trial
- Thalamocortical network dynamics can explain visual impulse responses and perceptual echoes.iScience · 2026Article
- Prognosis prediction of patients with disorders of consciousness based on digital twin brain models.Journal of neuroengineering and rehabilitation · 2026Article
- Cortical connectivity, local dynamics and stability correlates of global conscious states.Communications biology · 2025Article
- Parameter estimation in a whole-brain network model of epilepsy: Comparison of parallel global optimization solvers.PLoS computational biology · 2024Article
- The changing of α5-GABAA receptors expression and distribution participate in sevoflurane-induced learning and memory impairment in young mice.CNS neuroscience & therapeutics · 2024Article
- Differential Effect of Anesthesia on Visual Cortex Neurons with Diverse Population Coupling.Neuroscience · 2021Article
- Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review.Frontiers in synaptic neuroscience · 2021Review
- Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.Trends in pharmacological sciences · 2019Review
- Optimal Model Parameter Estimation from EEG Power Spectrum Features Observed during General Anesthesia.Neuroinformatics · 2018Article
- A Comparison of Multiscale Permutation Entropy Measures in On-Line Depth of Anesthesia Monitoring.PloS one · 2016Article
- A Mechanistic Neural Field Theory of How Anesthesia Suppresses Consciousness: Synaptic Drive Dynamics, Bifurcations, Attractors, and Partial State Equipartitioning.Journal of mathematical neuroscience · 2015Article
- How the cortico-thalamic feedback affects the EEG power spectrum over frontal and occipital regions during propofol-induced sedation.Journal of computational neuroscience · 2015Article
- Editorial: General anesthesia: from theory to experiments.Frontiers in systems neuroscience · 2015Article
- Statistical Frequency-Dependent Analysis of Trial-to-Trial Variability in Single Time Series by Recurrence Plots.Frontiers in systems neuroscience · 2015Article
- Neural field simulator: two-dimensional spatio-temporal dynamics involving finite transmission speed.Frontiers in neuroinformatics · 2015Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of extra-synaptic receptors in the regulation of excitation and inhibition in the brain has attracted increasing attention. Because activity in the extra-synaptic receptors plays a role in regulating the level of excitation and inhibition in the brain, they may be important in determining the level of consciousness. This paper reviews briefly the literature on extra-synaptic GABA and NMDA receptors and their affinity to anesthetic drugs. We propose a neural population model that illustrates how the effect of the anesthetic drug propofol on GABAergic extra-synaptic receptors results in changes in neural population activity and the electroencephalogram (EEG). Our results show that increased tonic inhibition in inhibitory cortical neurons cause a dramatic increase in the power of both δ- and α- bands. Conversely, the effects of increased tonic inhibition in cortical excitatory neurons and thalamic relay neurons have the opposite effect and decrease the power in these bands. The increased δ-activity is in accord with observed data for deepening propofol anesthesia; but is absolutely dependent on the inclusion of extrasynaptic (tonic) GABA action in the model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.