Evidence map›Paper›PMID 25540422›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2015

Mice are not men.

H Shaw Warren, Ronald G Tompkins, Lyle L Moldawer, Junhee Seok, Weihong Xu, Michael N Mindrinos, Ronald V Maier, Wenzhong Xiao, Ronald W Davis

2 registry-linked trialsAbstract readLetterComment
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00257231 completednot on this map

Inflammation and the Host Response to Injury

TypeobservationalSponsorMassachusetts General HospitalRan2003 to 2018Enrolled610ConditionsTrauma, Burns, Multiple Organ Failure
NCT00257244 completednot on this map

Inflammation and the Host Response to Injury

TypeobservationalSponsorMassachusetts General HospitalRan2004 to 2018Enrolled280ConditionsTrauma, Burns, Multiple Organ Failure
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Initiating factors for the onset of OA: A systematic review of animal bone and cartilage pathology in OA.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Experimental dissection of tuberculosis protective immunity: a human perspective.Frontiers in cellular and infection microbiology · 2025
    Review
  6. Review
  7. Humanized Mouse Models of Bacterial Infections.Antibiotics (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Article
  10. Functional Brain Changes Following Burn Injury: A Narrative Review.Neurorehabilitation and neural repair · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Transcriptomic congruence analysis for evaluating model organisms.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Review
  16. Understanding the immunological interactions of engineered nanomaterials: Role of the bio-corona.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022
    Review
  17. A roadmap for translational cancer glycoimmunology at single cell resolution.Journal of experimental & clinical cancer research : CR · 2022
    Review
  18. Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

H Shaw WarrenDepartments of Surgery, Medicine, and Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;
Ronald G TompkinsDepartments of Surgery, Medicine, and Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;
Lyle L MoldawerDepartment of Surgery, University of Florida, Gainesville, FL 32608;
Junhee SeokSchool of Electrical Engineering, Korea University, Seoul 136-713, Korea;
Weihong XuStanford Genome Technology Center, Stanford University, Palo Alto, CA 94305; and.
Michael N MindrinosStanford Genome Technology Center, Stanford University, Palo Alto, CA 94305; and.
Ronald V MaierDepartment of Surgery, Harborview Medical Center, Seattle, WA 98195.
Wenzhong XiaoDepartments of Surgery, Medicine, and Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; wenzhong.xiao@mgh.harvard.edu jeannet8@stanford.edu.
Ronald W DavisStanford Genome Technology Center, Stanford University, Palo Alto, CA 94305; and wenzhong.xiao@mgh.harvard.edu jeannet8@stanford.edu.

Funding

Inflammation and the Response to InjuryU54GM062119 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI DAVIS, RONALD WAYNE · 2001 to 2010
$78.6M
Validation of a Genomics Based Prognostic in Severe TraumaR01GM104481 · NIGMS · UNIVERSITY OF FLORIDA · PI MOLDAWER, LYLE L · 2013 to 2016
$1.8M
Bridging Sustainable Distribution of TRBD Bioinformatics ResourcesR24GM102656 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI XIAO, WENZHONG · 2012 to 2014
$1.6M
NIGMS NIH HHS R01 GM104481NIGMS NIH HHS U54 GM062119
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Databases, GeneticDisease Models, AnimalGene Expression ProfilingGene Expression RegulationInflammationAnimalsHumans

Identifiers

PMID25540422
PMCPMC4313842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.