ArticleProceedings of the National Academy of Sciences of the United States of America2015
Energetic basis for the molecular-scale organization of bone.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 75 citations in OpenAlex.
- Revisiting the inorganic component of bone: beyond the accepted concept of "mineral".Scientific reports · 2026Article
- Molecular-level understanding of the aging bone and regeneration mechanisms using computational methods.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Cross-linking of collagen fibrils leads to preferential gap zone mineralization in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Role of Confinement in Biomineralization.Chemical reviews · 2025Review
- Investigating the influence of mineral content changes on mechanical properties through ligament insertion.Frontiers in aging · 2025Article
- Effect of the Correction of Bilateral Differences in Masseter Muscle Functional Pressure on the Mandible of Growing Rats.Journal of functional biomaterials · 2023Article
- Self-Assembly of Elastin-like Polypeptide Brushes on Silica Surfaces and Nanoparticles.Biomacromolecules · 2021Article
- Intermolecular channels direct crystal orientation in mineralized collagen.Nature communications · 2020Article
- Chiral Tartaric Acid Improves Fracture Toughness of Bioactive Brushite-Collagen Bone Cements.ACS applied bio materials · 2020Article
- Bioenergetic-active materials enhance tissue regeneration by modulating cellular metabolic state.Science advances · 2020Article
- Hierarchically oriented organization in supramolecular peptide crystals.Protein and peptide letters · 2019Article
- Controlling protein assembly on inorganic crystals through designed protein interfaces.Nature · 2019Article
- Transformation of amorphous calcium phosphate to bone-like apatite.Nature communications · 2018Article
- Developing a molecular picture of soil organic matter-mineral interactions by quantifying organo-mineral binding.Nature communications · 2017Article
- Quantifying the free energy landscape between polymers and minerals.Scientific reports · 2017Article
- Article
- Atomic scale chemical tomography of human bone.Scientific reports · 2017Article
- Amelogenin Affects Brushite Crystal Morphology and Promotes Its Phase Transformation to Monetite.Crystal growth & design · 2016Article
- Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils.Journal of the Royal Society, Interface · 2016Review
- Bone mineral properties in growing Col1a2(+/G610C) mice, an animal model of osteogenesis imperfecta.Bone · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The remarkable properties of bone derive from a highly organized arrangement of coaligned nanometer-scale apatite platelets within a fibrillar collagen matrix. The origin of this arrangement is poorly understood and the crystal structures of hydroxyapatite (HAP) and the nonmineralized collagen fibrils alone do not provide an explanation. Moreover, little is known about collagen-apatite interaction energies, which should strongly influence both the molecular-scale organization and the resulting mechanical properties of the composite. We investigated collagen-mineral interactions by combining dynamic force spectroscopy (DFS) measurements of binding energies with molecular dynamics (MD) simulations of binding and atomic force microscopy (AFM) observations of collagen adsorption on single crystals of calcium phosphate for four mineral phases of potential importance in bone formation. In all cases, we observe a strong preferential orientation of collagen binding, but comparison between the observed orientations and transmission electron microscopy (TEM) analyses of native tissues shows that only calcium-deficient apatite (CDAP) provides an interface with collagen that is consistent with both. MD simulations predict preferred collagen orientations that agree with observations, and results from both MD and DFS reveal large values for the binding energy due to multiple binding sites. These findings reconcile apparent contradictions inherent in a hydroxyapatite or carbonated apatite (CAP) model of bone mineral and provide an energetic rationale for the molecular-scale organization of bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.