Evidence map›Paper›PMID 25540398›Full record

ReviewJournal of clinical microbiology2015

Bartonella, a common cause of endocarditis: a report on 106 cases and review.

Sophie Edouard, Cecile Nabet, Hubert Lepidi, Pierre-Edouard Fournier, Didier Raoult

Open access · bronzeAbstract readCase ReportsReview
In one paragraph

Review in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 1 synthesis or guideline pooled it, 167 citations in OpenAlex.

  1. Pathogens (Basel, Switzerland) · 2024
    Pooled it
  2. Review
  3. Molecular investigation ofNew microbes and new infections · 2026
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  5. Never say never.Journal of hospital medicine · 2026
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  7. Scratches of danger: fromEuropean heart journal. Case reports · 2026
    Article
  8. Article
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  10. Microbiology spectrum · 2025
    Article
  11. Article
  12. Open heart · 2025
    Article
  13. Review
  14. Repeated Detection ofAnimals : an open access journal from MDPI · 2025
    Article
  15. Review
  16. Experimental Infection of Ferrets withPathogens (Basel, Switzerland) · 2025
    Article
  17. Kidney international reports · 2025
    Article
  18. Review
  19. Article
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sophie EdouardAix Marseille Université, URMITE, UM63, CNRS 7278, IRD198, Inserm 1095, Marseille, France.
Cecile NabetAix Marseille Université, URMITE, UM63, CNRS 7278, IRD198, Inserm 1095, Marseille, France.
Hubert LepidiAix Marseille Université, URMITE, UM63, CNRS 7278, IRD198, Inserm 1095, Marseille, France.
Pierre-Edouard FournierAix Marseille Université, URMITE, UM63, CNRS 7278, IRD198, Inserm 1095, Marseille, France.
Didier RaoultAix Marseille Université, URMITE, UM63, CNRS 7278, IRD198, Inserm 1095, Marseille, France didier.raoult@gmail.com.
Aix-Marseille Université · FRInserm · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bartonella spp. are fastidious bacteria that cause blood culture-negative endocarditis and have been increasingly reported. In this study, we included all patients retrospectively and prospectively diagnosed with Bartonella endocarditis in our French reference center between 2005 and 2013. Our diagnosis was based on the modified Duke criteria and microbiological findings, including serological and PCR results. To review the published literature, we searched all human Bartonella endocarditis cases published in the PubMed database between January 2005 and October 2013. We report here a large series of 106 cases, which include 59 cases that had not previously been reported or mentioned. Indirect immunofluorescence assays, Western blotting, and real-time PCR from total blood, serum, and valve tissue exhibited sensitivities of 58%, 100%, 33%, 36%, and 91%, respectively. The number of cases reported in the literature between 2005 and 2013 increased to reach a cumulative number of 196 cases. The number of cases reported in the literature by other centers is increasing more rapidly than that reported by our French reference center (P < 10(-2)). Currently, there is a lack of criteria for the diagnosis of Bartonella endocarditis. We suggest that a positive PCR result from a cardiac valve or blood specimen, an IgG titer of ≥800 using an immunofluorescence assay, or a positive Western blot assay be considered major Duke criteria for Bartonella endocarditis. There is no real increase in the incidence of these infections but rather a better understanding and interest in the disease resulting from the improvement of diagnostic tools.

Indexed as

AdultAgedAntibodies, BacterialBartonellaBartonella InfectionsBloodBlotting, WesternEndocarditis, BacterialFemaleFluorescent Antibody TechniqueFranceGlobal HealthHeart ValvesHumansIncidenceMaleAntibodies, Bacterial

Identifiers

PMID25540398
PMCPMC4390654
OpenAlexW2060682087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.