Evidence map›Paper›PMID 25540323›Full record

ArticleScience translational medicine2014

Reply to comment on "An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice".

Yvette I Sheline, Tim West, Kevin Yarasheski, Mateusz S Jasielec, Jane C Hettinger, Danielle L Tripoli, Chengjie Xiong, Christine Frederiksen, Monica V Grzelak, Randall J Bateman and 3 more

Open access · greenAbstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Serotonin, neural markers, and memory.Frontiers in pharmacology · 2015
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yvette I ShelineDepartments of Psychiatry, Radiology, and Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA. sheline@mail.med.upenn.edu.
Tim WestC2N Diagnostics LLC, St. Louis, MO 63110, USA.
Kevin YarasheskiDepartment of Medicine, Washington University, St. Louis, MO 63110, USA.
Mateusz S JasielecDepartment of Biostatistics, Washington University, St. Louis, MO 63110, USA.
Jane C HettingerDepartment of Neurology, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA. Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.
Danielle L TripoliDepartment of Neurology, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA. Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.
Chengjie XiongDepartment of Biostatistics, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA.
Christine FrederiksenDepartment of Surgery, Washington University, St. Louis, MO 63110, USA.
Monica V GrzelakKnight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA.
Randall J BatemanDepartment of Neurology, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA. Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.
John C MorrisDepartment of Neurology, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA.
Jin-Moo LeeDepartment of Neurology, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA. Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.
John R CirritoDepartment of Neurology, Washington University, St. Louis, MO 63110, USA. Knight Alzheimer's Disease Research Center, Washington University Medical Center, St. Louis, MO 63110, USA. Hope Center for Neurological Disorders, Washington University, St. Louis, MO 63110, USA.
Washington University in St. Louis · USHope Center for Neurological Disorders · US

Funding

Viral Vectors CoreP01NS074969 · NINDS · WASHINGTON UNIVERSITY · PI SNIDER, BARBARA JOY · 2012 to 2021
$13.0M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
CITALOPRAM DECREASES CSF AB: A RANDOMIZED DOSE FINDING TRIALR01AG041502 · NIA · WASHINGTON UNIVERSITY · PI SHELINE, YVETTE I · 2012 to 2015
$1.8M
SYNAPTIC REGULATION OF ERK-MEDIATED AMYLOID-BETA METABOLISMR01AG042513 · NIA · WASHINGTON UNIVERSITY · PI CIRRITO, JOHN R · 2012 to 2016
$1.5M
ENHANCING LYSOSOME BIOGENESIS TO PREVENT AMYLOID PLAQUE PATHOGENESISR21NS082529 · NINDS · WASHINGTON UNIVERSITY · PI LEE, JIN-MOO · 2013 to 2014
$416k
NIA NIH HHS R01 AG041502NIA NIH HHS R01 AG042513NIGMS NIH HHS P41 GM103422NINDS NIH HHS P01 NS074969NINDS NIH HHS R21 NS082529
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsAntidepressive AgentsCitalopramFemaleHumansMaleAmyloid beta-Protein PrecursorAntidepressive AgentsCitalopram

Identifiers

PMID25540323
PMCPMC4778730
OpenAlexW2029246747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.