ArticleProceedings. Biological sciences2015
Cardiac function in an endothermic fish: cellular mechanisms for overcoming acute thermal challenges during diving.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Effects of acute cold stress on the physiological and biochemical dynamics of Nile tilapia (Oreochromis niloticus Linn.): in vivo and in vitro studies.Fish physiology and biochemistry · 2026Article
- Surfacing and diving behavior associated with thermal physiology in oceanic habitats of skipjack tuna (Frontiers in physiology · 2025Article
- Ontogeny of cardiomyocytes: ultrastructure optimization to meet the demand for tight communication in excitation-contraction coupling and energy transfer.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Effect of thermal variation on the cardiac thermal limits of a eurythermal marine teleost (Current research in physiology · 2022Article
- Effects of acute warming on cardiac and myotomal sarco(endo)plasmic reticulum ATPase (SERCA) of thermally acclimated brown trout (Salmo trutta).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Thermal effects on red muscle contractile performance in deep-diving, large-bodied fishes.Fish physiology and biochemistry · 2020Article
- Skeletal muscle and cardiac transcriptomics of a regionally endothermic fish, the Pacific bluefin tuna, Thunnus orientalis.BMC genomics · 2020Article
- Environmental influences and ontogenetic differences in vertical habitat use of black marlin (Royal Society open science · 2017Article
- Temperature-induced cardiac remodelling in fish.The Journal of experimental biology · 2017Review
- Fisheries conservation on the high seas: linking conservation physiology and fisheries ecology for the management of large pelagic fishes.Conservation physiology · 2016Article
- Temperature-dependence of L-type Ca(2+) current in ventricular cardiomyocytes of the Alaska blackfish (Dallia pectoralis).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Article
- Direct quantification of energy intake in an apex marine predator suggests physiology is a key driver of migrations.Science advances · 2015Article
- Heterogeneous natural selection on oxidative phosphorylation genes among fishes with extreme high and low aerobic performance.BMC evolutionary biology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the physiology of vertebrate thermal tolerance is critical for predicting how animals respond to climate change. Pacific bluefin tuna experience a wide range of ambient sea temperatures and occupy the largest geographical niche of all tunas. Their capacity to endure thermal challenge is due in part to enhanced expression and activity of key proteins involved in cardiac excitation-contraction coupling, which improve cardiomyocyte function and whole animal performance during temperature change. To define the cellular mechanisms that enable bluefin tuna hearts to function during acute temperature change, we investigated the performance of freshly isolated ventricular myocytes using confocal microscopy and electrophysiology. We demonstrate that acute cooling and warming (between 8 and 28°C) modulates the excitability of the cardiomyocyte by altering the action potential (AP) duration and the amplitude and kinetics of the cellular Ca(2+) transient. We then explored the interactions between temperature, adrenergic stimulation and contraction frequency, and show that when these stressors are combined in a physiologically relevant way, they alter AP characteristics to stabilize excitation-contraction coupling across an acute 20°C temperature range. This allows the tuna heart to maintain consistent contraction and relaxation cycles during acute thermal challenges. We hypothesize that this cardiac capacity plays a key role in the bluefin tunas' niche expansion across a broad thermal and geographical range.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.