ReviewPhysiological reviews2015
Leukocyte homing, fate, and function are controlled by retinoic acid.
Review in Physiological reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026Review
- Apoptotic-mimetic nanovesicles orchestrate immune-vascular-osteogenic crosstalk for critical-sized craniofacial bone regeneration.Materials today. Bio · 2026Article
- Nutritional Support of Chronic Obstructive Pulmonary Disease.Nutrients · 2025Review
- Retinoic acid signaling acts as a rheostat to balance Treg function.Cellular & molecular immunology · 2022Article
- Review
- AllCurrent research in immunology · 2022Review
- Spaceflight Analogue Culture Enhances the Host-Pathogen Interaction BetweenFrontiers in cellular and infection microbiology · 2022Article
- Vitamin A in resistance to and recovery from infection: relevance to SARS-CoV2.The British journal of nutrition · 2021Review
- Article
- Aberrant retinoic acid production in the decidua: Implications for pre-eclampsia.The journal of obstetrics and gynaecology research · 2020Review
- Alternatively Activated Macrophages Are the Primary Retinoic Acid-Producing Cells in Human Decidua.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Vitamin A Deficiency and the Lung.Nutrients · 2018Review
- Non-Provitamin A and Provitamin A Carotenoids as Immunomodulators: Recommended Dietary Allowance, Therapeutic Index, or Personalized Nutrition?Oxidative medicine and cellular longevity · 2018Review
- Transcription factor ISX mediates the cross talk between diet and immunity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Impact of Vitamin A and Carotenoids on the Risk of Tuberculosis Progression.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Low plasma vitamin A concentration is associated with tuberculosis in Moroccan population: a preliminary case control study.BMC research notes · 2017Article
- Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models.Advances in nutrition (Bethesda, Md.) · 2017Review
- CD161Frontiers in immunology · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Although vitamin A was recognized as an "anti-infective vitamin" over 90 years ago, the mechanism of how vitamin A regulates immunity is only beginning to be understood. Early studies which focused on the immune responses in vitamin A-deficient (VAD) animals clearly demonstrated compromised immunity and consequently increased susceptibility to infectious disease. The active form of vitamin A, retinoic acid (RA), has been shown to have a profound impact on the homing and differentiation of leukocytes. Both pharmacological and genetic approaches have been applied to the understanding of how RA regulates the development and differentiation of various immune cell subsets, and how RA influences the development of immunity versus tolerance. These studies clearly show that RA profoundly impacts on cell- and humoral-mediated immunity. In this review, the early findings on the complex relationship between VAD and immunity are discussed as well as vitamin A metabolism and signaling within hematopoietic cells. Particular attention is focused on how RA impacts on T-cell lineage commitment and plasticity in various diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.