Evidence map›Paper›PMID 25540117›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2016

Induced Pluripotent Stem Cells from Nonhuman Primates.

Anuja Mishra, Zhifang Qiu, Steven L Farnsworth, Jacob J Hemmi, Miao Li, Alexander V Pickering, Peter J Hornsby

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Non-human primate: the new frontier model of female reproductive engineering.Frontiers in bioengineering and biotechnology · 2025
    Review
  2. Reconstructing human-specific regulatory functions in model systems.Current opinion in genetics & development · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anuja MishraSouth Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.
Zhifang QiuSouth Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.
Steven L FarnsworthSouth Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.
Jacob J HemmiSouth Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.
Miao LiSouth Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.
Alexander V PickeringSouth Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA.
Peter J HornsbySouth Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, TX, USA. hornsby@uthscsa.edu.

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
Institutional Research Training GrantT32DE014318 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Kenneth M Hargreaves · 2002 to 2026
$12.1M
TRAINING GRANT ON THE BIOLOGY OF AGINGT32AG021890 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Erzsebet Kokovay, JAMES FLOYD NELSON · 2003 to 2026
$11.4M
Aging and Reprogramming of Somatic Cells to PluripotencyR21AG033286 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HORNSBY, PETER J · 2009 to 2010
$303k
Establishment of Marmoset iPS-derived Cranial Neural Crest CellsF30DE022494 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FARNSWORTH, STEVEN · 2012 to 2016
$202k
Stress resistance in neurons from primate iPS cellsR03AG045481 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HORNSBY, PETER J · 2013 to 2014
$150k
Nonhuman primate induced pluripotent stem cells in regenerative medicineI01BX001454 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI HORNSBY, PETER J · 2012 to 2015
–
BLRD VA I01 BX001454NCATS NIH HHS UL1 TR001120NIA NIH HHS P30 AG013319NIA NIH HHS R03 AG045481NIA NIH HHS R21 AG033286NIA NIH HHS T32 AG021890NIDCR NIH HHS F30 DE022494NIDCR NIH HHS T32 DE014318
6 · The paper itself

Abstract

Induced pluripotent stem cells from nonhuman primates (NHPs) have unique roles in cell biology and regenerative medicine. Because of the relatedness of NHPs to humans, NHP iPS cells can serve as a source of differentiated derivatives that can be used to address important questions in the comparative biology of primates. Additionally, when used as a source of cells for regenerative medicine, NHP iPS cells serve an invaluable role in translational experiments in cell therapy. Reprogramming of NHP somatic cells requires the same conditions as previously established for human cells. However, throughout the process, a variety of modifications to the human cell protocols must be made to accommodate significant species differences.

Indexed as

PrimatesTransgenesAnimalsCallithrixCell Culture TechniquesCells, CulturedCellular ReprogrammingCellular Reprogramming TechniquesFibroblastsGenes, mycGenetic VectorsHumansInduced Pluripotent Stem CellsKruppel-Like Factor 4Kruppel-Like Transcription FactorsMiceKruppel-Like Factor 4Kruppel-Like Transcription FactorsOctamer Transcription Factor-3Proto-Oncogene Proteins c-mybSOXB1 Transcription FactorsInduced pluripotent stem cellsMarmosetNonhuman primatesReprogrammingRetrovirusesTeratoma

Identifiers

PMID25540117
PMCPMC4483148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.