ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Characterizing rapid-onset vasodilation to single muscle contractions in the human leg.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Orthostatic-dependent cardiopulmonary responses among trained females during intensity matched resistance exercises in a pilot randomized crossover study.Scientific reports · 2025Trial
- Macro- and microcirculatory factors affecting foot temperature change during walking.Experimental physiology · 2026Article
- Role of Resistance Exercise in Cardiology.Anatolian journal of cardiology · 2024Article
- Making the case for resistance training in improving vascular function and skeletal muscle capillarization.Frontiers in physiology · 2024Review
- Uphill versus downhill high-intensity training effectiveness in preserving vascular function and exercise performance in runners who reduce their regular endurance training.Sport sciences for health · 2023Article
- Indices of leg resistance artery function are independently related to cycling V̇OPhysiological reports · 2020Article
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Central cardiovascular hemodynamic response to unilateral handgrip exercise with blood flow restriction.European journal of applied physiology · 2019Article
- Age-associated impairments in contraction-induced rapid-onset vasodilatation within the forearm are independent of mechanical factors.Experimental physiology · 2018Article
- Influence of physical inactivity on arterial compliance during a glucose challenge.Experimental physiology · 2018Article
- Regular Aerobic, Resistance, and Cross-Training Exercise Prevents Reduced Vascular Function Following a High Sugar or High Fat Mixed Meal in Young Healthy Adults.Frontiers in physiology · 2018Article
- Hyper-Oxygenation Attenuates the Rapid Vasodilatory Response to Muscle Contraction and Compression.Frontiers in physiology · 2018Article
- Rapid versus slow ascending vasodilatation: intercellular conduction versus flow-mediated signalling with tetanic versus rhythmic muscle contractions.The Journal of physiology · 2017Article
- Age-related differences in skeletal muscle microvascular response to exercise as detected by contrast-enhanced ultrasound (CEUS).PloS one · 2017Article
- Differential α-adrenergic modulation of rapid onset vasodilatation along resistance networks of skeletal muscle in old versus young mice.The Journal of physiology · 2016Article
- FloWave.US: validated, open-source, and flexible software for ultrasound blood flow analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Attenuated rapid onset vasodilation with greater force production in skeletal muscle of caveolin-2-/- mice.American journal of physiology. Heart and circulatory physiology · 2016Article
- Mechanical compression during repeated sustained isometric muscle contractions and hyperemic recovery in healthy young males.Journal of physiological anthropology · 2015Article
- Rapid onset vasodilation with single muscle contractions in the leg: influence of age.Physiological reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Rapid-onset vasodilation (ROV) following single muscle contractions has been examined in the forearm of humans, but has not yet been characterized in the leg. Given known vascular differences between the arm and leg, we sought to characterize ROV following single muscle contractions in the leg. Sixteen healthy men performed random ordered single contractions at 5, 10, 20, 40, and 60% of their maximum voluntary contraction (MVC) using isometric knee extension made with the leg above and below heart level, and these were compared with single isometric contractions of the forearm (handgrip). Single thigh cuff compressions (300 mmHg) were utilized to estimate the mechanical contribution to leg ROV. Continuous blood flow was determined by duplex-Doppler ultrasound and blood pressure via finger photoplethysmography (Finometer). Single isometric knee extensor contractions produced intensity-dependent increases in peak leg vascular conductance that were significantly greater than the forearm in both the above- and below-heart level positions (e.g., above heart level: leg 20% MVC, +138 ± 28% vs. arm 20% MVC, +89 ± 17%; P < 0.05). Thigh cuff compressions also produced a significant hyperemic response, but these were brief and smaller in magnitude compared with single isometric contractions in the leg. Collectively, these data demonstrate the presence of a rapid and robust vasodilation to single muscle contractions in the leg that is largely independent of mechanical factors, thus establishing the leg as a viable model to study ROV in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.