ArticleNucleic acids research2015
Regulation of the transcriptional program by DNA methylation during human αβ T-cell development.
Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- A tumor suppressor role of the miR-15b/16-2 cluster in T-cell acute lymphoblastic leukemia.Blood · 2026Article
- Targeting epigenetic regulators to boost T cell immunotherapy against cancer.Cell & bioscience · 2026Review
- Subtyping Burkitt Lymphoma by DNA Methylation.Genes, chromosomes & cancer · 2025Article
- Epigenome-wide association study on methamphetamine dependence.Addiction biology · 2024Article
- Dysregulation of epigenetic modifications in inborn errors of immunity.Epigenomics · 2024Review
- Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells.Frontiers in immunology · 2024Article
- Human CD4 T Cells From Thymus and Cord Blood Are Convertible Into CD8 T Cells by IL-4.Frontiers in immunology · 2022Article
- Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome.Nature communications · 2021Article
- Defining a Methylation Signature Associated With Operational Tolerance in Kidney Transplant Recipients.Frontiers in immunology · 2021Article
- High expression of KITLG is a new hallmark activating the MAPK pathway in type A and AB thymoma.Thoracic cancer · 2020Article
- DNA methylation-based classification reveals difference between pediatric T-cell acute lymphoblastic leukemia and normal thymocytes.Leukemia · 2020Article
- DNA Methylation in T-Cell Development and Differentiation.Critical reviews in immunology · 2020Review
- DNA methylation as a transcriptional regulator of the immune system.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Continuous Developmental and Early Life Trichloroethylene Exposure Promoted DNA Methylation Alterations in Polycomb Protein Binding Sites in Effector/Memory CD4Frontiers in immunology · 2019Article
- Epigenetic underpinnings of developmental immunotoxicity and autoimmune disease.Current opinion in toxicology · 2018Article
- Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Comparison of Genome-Wide and Gene-Specific DNA Methylation Profiling in First-Trimester Chorionic Villi From Pregnancies Conceived With Infertility Treatments.Reproductive sciences (Thousand Oaks, Calif.) · 2017Article
- Phenotypic characteristics of aged CD4Aging cell · 2017Article
- Stem Cells from Dental Pulp: What Epigenetics Can Do with Your Tooth.Frontiers in physiology · 2017Review
- TET Methylcytosine Oxidases in T Cell and B Cell Development and Function.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thymocyte differentiation is a complex process involving well-defined sequential developmental stages that ultimately result in the generation of mature T-cells. In this study, we analyzed DNA methylation and gene expression profiles at successive human thymus developmental stages. Gain and loss of methylation occurred during thymocyte differentiation, but DNA demethylation was much more frequent than de novo methylation and more strongly correlated with gene expression. These changes took place in CpG-poor regions and were closely associated with T-cell differentiation and TCR function. Up to 88 genes that encode transcriptional regulators, some of whose functions in T-cell development are as yet unknown, were differentially methylated during differentiation. Interestingly, no reversion of accumulated DNA methylation changes was observed as differentiation progressed, except in a very small subset of key genes (RAG1, RAG2, CD8A, PTCRA, etc.), indicating that methylation changes are mostly unique and irreversible events. Our study explores the contribution of DNA methylation to T-cell lymphopoiesis and provides a fine-scale map of differentially methylated regions associated with gene expression changes. These can lay the molecular foundations for a better interpretation of the regulatory networks driving human thymopoiesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.