ArticlePhysiological reports2014
Endurance exercise induces REDD1 expression and transiently decreases mTORC1 signaling in rat skeletal muscle.
Article in Physiological reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- NeuronaleNeuro · 2026Article
- Unilateral isometric contraction induces REDD1 and suppresses insulin-stimulated mTORC1 and protein synthesis in non-contracted muscle of male mice.Physiological reports · 2025Article
- Differential responses to acute endurance exercise-induced signaling protein phosphorylation and abundance alterations in whole murine gastrocnemius muscle and isolated myofibers.Current research in physiology · 2025Article
- Mixed twitch and tetanus electrical stimulation via belt-electrode effectively attenuates denervation-induced muscle atrophy.PloS one · 2025Article
- Exercise-mediated IL-6 downstream effects modulate brain pathology-can exercise training protocols influence the downstream effects?Frontiers in neurology · 2025Review
- Beneficial effects of a novel polyherbal formulation on the skeletal muscle antioxidant status, inflammation, and muscle-signaling proteins in exercised rats.Turkish journal of biology = Turk biyoloji dergisi · 2024Article
- Resveratrol improves palmitic acid‑induced insulin resistance via the DDIT4/mTOR pathway in C2C12 cells.Molecular medicine reports · 2023Article
- The stress-responsive protein REDD1 and its pathophysiological functions.Experimental & molecular medicine · 2023Review
- Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.ACS chemical biology · 2023Article
- REDD1 deletion and treadmill running increase liver hepcidin and gluconeogenic enzymes in male mice.Journal of nutritional science · 2023Article
- Co-ingestion of glutamine and leucine synergistically promotes mTORC1 activation.Scientific reports · 2022Article
- Exercise reduces the protein abundance of TXNIP and its interacting partner REDD1 in skeletal muscle: potential role for a PKA-mediated mechanism.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Epigenetic memory: gene writer, eraser and homocysteine.Molecular and cellular biochemistry · 2021Review
- One Bout of Aerobic Exercise Can Enhance the Expression ofFrontiers in physiology · 2021Article
- Dysbiotic 1-carbon metabolism in cardiac muscle remodeling.Journal of cellular physiology · 2020Article
- Epigenetics, 1-Carbon Metabolism, and Homocysteine During Dysbiosis.Frontiers in physiology · 2020Article
- Acute treadmill exercise discriminately improves the skeletal muscle insulin-stimulated growth signaling responses in mice lacking REDD1.Physiological reports · 2019Article
- Branched-chain amino acids administration suppresses endurance exercise-related activation of ubiquitin proteasome signaling in trained human skeletal muscle.The journal of physiological sciences : JPS · 2018Article
- REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise.American journal of physiology. Endocrinology and metabolism · 2017Article
- Divergent Anabolic Signalling responses of Murine Soleus and Tibialis Anterior Muscles to Chronic 2G Hypergravity.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Working muscle conserves adenosine triphosphate (ATP) for muscle contraction by attenuating protein synthesis through several different pathways. Regulated in development and DNA damage response 1 (REDD1) is one candidate protein that can itself attenuate muscle protein synthesis during muscle contraction. In this study, we investigated whether endurance exercise induces REDD1 expression in association with decreased mammalian target of rapamycin (mTOR) complex I (mTORC1) signaling and global protein synthesis in rat skeletal muscle. After overnight fasting, rats ran on a treadmill at a speed of 28 m/min for 60 min, and were killed before and immediately, 1, 3, 6, 12, and 24 h after exercise. REDD1 mRNA and corresponding protein levels increased rapidly immediately after exercise, and gradually decreased back to the basal level over a period of 6 h in the gastrocnemius muscle. Phosphorylation of mTOR Ser2448 and S6K1 Thr389 increased with the exercise, but diminished in 1-3 h into the recovery period after cessation of exercise. The rate of protein synthesis, as determined by the surface sensing of translation (SUnSET) method, was not altered by exercise in fasted muscle. These results suggest that REDD1 attenuates exercise-induced mTORC1 signaling. This may be one mechanism responsible for blunting muscle protein synthesis during exercise and in the early postexercise recovery period.
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