ArticleVirology journal2014
Sampling variability between two mid-turbinate swabs of the same patient has implications for influenza viral load monitoring.
Article in Virology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Comparison of self-collected oral-nasal and mid-turbinate swabs to healthcare worker-collected nasopharyngeal swabs for the detection of SARS-CoV-2: a paired clinical evaluation.Access microbiology · 2026Article
- Article
- Diagnostic Accuracy of an At-Home, Rapid Self-test for Influenza: Prospective Comparative Accuracy Study.JMIR public health and surveillance · 2022Article
- Immune-viral dynamics modeling for SARS-CoV-2 drug development.Clinical and translational science · 2021Article
- Reduced sensitivity of SARS-CoV-2 PCR testing with single-nostril nasal swabs.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2021Article
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- Article
- Article
- Polyester nasal swabs collected in a dry tube are a robust and inexpensive, minimal self-collection kit for SARS-CoV-2 testing.PloS one · 2021Article
- Establishing a mass spectrometry-based system for rapid detection of SARS-CoV-2 in large clinical sample cohorts.Nature communications · 2020Article
- Testing for Severe Acute Respiratory Syndrome-Coronavirus 2: Challenges in Getting Good Specimens, Choosing the Right Test, and Interpreting the Results.Critical care medicine · 2020Article
- Asymptomatic and presymptomatic transmission of SARS-CoV-2: A systematic review.medRxiv : the preprint server for health sciences · 2020Article
- Cellular DNA quantification in respiratory samples for the normalization of viral load: a real need?Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2018Article
- Comparative Viral Sampling in the Sinonasal Passages; Different Viruses at Different Sites.Frontiers in cellular and infection microbiology · 2018Article
- Human Bocavirus Capsid Messenger RNA Detection in Children With Pneumonia.The Journal of infectious diseases · 2017Article
- Sampling and detection of airborne influenza virus towards point-of-care applications.PloS one · 2017Article
- A Downward Trend of the Ratio of Influenza RNA Copy Number to Infectious Viral Titer in Hospitalized Influenza A-Infected Patients.Open forum infectious diseases · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith the clinical development of several antiviral intervention strategies for influenza, it becomes crucial to explore viral load shedding in the nasal cavity as a biomarker for treatment success, but also to explore sampling strategies for sensible and reliable virus collection.
findingsIn this study, 244 patients suffering from Influenza like Illness and/or acute respiratory tract infection were enrolled. Sampling was done using mid-turbinate flocked swabs and two swabs per patient were collected (one swab per nostril). The influenza A viral loads of two mid-turbinate flocked swabs (one for each nostril) per patient were compared and we have also assessed whether normalization for human cellular DNA in the swabs could be useful. The Influenza mid-turbinate nasal swab testing resulted in considerable sampling variability that could not be normalized against co-isolated human cellular DNA.
conclusionsInfluenza viral load monitoring in nasal swabs could be very valuable as virological endpoints in clinical trials to monitor treatment efficacy, in analogy to HIV, HBV & HCV viral load monitoring. However, the differences between left and right nostrils, as observed in this study, highlight the importance of proper sampling and the need for standardized sampling procedures.
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