ArticleGenome biology and evolution2014
Functional annotation of the Ophiostoma novo-ulmi genome: insights into the phytopathogenicity of the fungal agent of Dutch elm disease.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- An Ammonium Transporter Gene Contributes to the Aggressiveness of the Dutch Elm Disease PathogenJournal of fungi (Basel, Switzerland) · 2026Article
- Status of Dutch Elm Disease Fungus Ophiostoma novo-ulmi and Assessment of Its Temporal Variability in Croatia.Microbial ecology · 2025Article
- Genomic Exploration of Climate-driven Evolution and Evolutionary Convergence in Forest Pathogens.Genome biology and evolution · 2025Article
- Extracting Protoplasts from Filamentous Fungi Using Extralyse, An Enzyme Used in the Wine Industry.Current protocols · 2025Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Unraveling the transcriptional features and gene expression networks of pathogenic and saprotrophicMicrobiology spectrum · 2024Article
- Insight into the genomes of dominant yeast symbionts of European spruce bark beetle,Frontiers in microbiology · 2023Article
- Independent Evolution Has Led to Distinct Genomic Signatures in Dutch Elm Disease-Causing Fungi and Other Vascular Wilts-Causing Fungal Pathogens.Journal of fungi (Basel, Switzerland) · 2022Article
- Comparative Analysis of Transcriptomes ofJournal of fungi (Basel, Switzerland) · 2022Article
- Different Responses in Vascular Traits between Dutch Elm Hybrids with a Contrasting Tolerance to Dutch Elm Disease.Journal of fungi (Basel, Switzerland) · 2022Article
- Deciphering the Genome-Wide Transcriptomic Changes during Interactions of Resistant and Susceptible Genotypes of American Elm withJournal of fungi (Basel, Switzerland) · 2022Article
- Achievements and Challenges of Genomics-Assisted Breeding in Forest Trees: From Marker-Assisted Selection to Genome Editing.International journal of molecular sciences · 2021Review
- Article
- An Efficient Strategy for Obtaining Mutants by Targeted Gene Deletion inFrontiers in microbiology · 2021Article
- Investigating the Smuts: Common Cues, Signaling Pathways, and the Role ofJournal of fungi (Basel, Switzerland) · 2020Review
- Comparative Genomics Analyses of Lifestyle Transitions at the Origin of an Invasive Fungal Pathogen in the GenusmSphere · 2020Article
- Comparative RNAseq Analysis of the Insect-Pathogenic FungusG3 (Bethesda, Md.) · 2020Article
- Hybridization and introgression drive genome evolution of Dutch elm disease pathogens.Nature ecology & evolution · 2020Article
- CRISPR/Cas9 Gene Editing: An Unexplored Frontier for Forest Pathology.Frontiers in plant science · 2020Review
- Microbial invasions in terrestrial ecosystems.Nature reviews. Microbiology · 2019Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ascomycete fungus Ophiostoma novo-ulmi is responsible for the pandemic of Dutch elm disease that has been ravaging Europe and North America for 50 years. We proceeded to annotate the genome of the O. novo-ulmi strain H327 that was sequenced in 2012. The 31.784-Mb nuclear genome (50.1% GC) is organized into 8 chromosomes containing a total of 8,640 protein-coding genes that we validated with RNA sequencing analysis. Approximately 53% of these genes have their closest match to Grosmannia clavigera kw1407, followed by 36% in other close Sordariomycetes, 5% in other Pezizomycotina, and surprisingly few (5%) orphans. A relatively small portion (∼3.4%) of the genome is occupied by repeat sequences; however, the mechanism of repeat-induced point mutation appears active in this genome. Approximately 76% of the proteins could be assigned functions using Gene Ontology analysis; we identified 311 carbohydrate-active enzymes, 48 cytochrome P450s, and 1,731 proteins potentially involved in pathogen-host interaction, along with 7 clusters of fungal secondary metabolites. Complementary mating-type locus sequencing, mating tests, and culturing in the presence of elm terpenes were conducted. Our analysis identified a specific genetic arsenal impacting the sexual and vegetative growth, phytopathogenicity, and signaling/plant-defense-degradation relationship between O. novo-ulmi and its elm host and insect vectors.
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