ArticleAmerican journal of physiology. Heart and circulatory physiology2015
Angiotensin II type 1a receptors in subfornical organ contribute towards chronic intermittent hypoxia-associated sustained increase in mean arterial pressure.
Article in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 45 citations in OpenAlex.
- Brain nitric oxide and inflammation in chronic intermittent hypoxia: Contributors to cognitive impairment and hypertension.Brain, behavior, & immunity - health · 2025Review
- Chronic intermittent hypoxia and ovariectomy exert independent and region-specific effects on ΔFosB expression and increase blood pressure in female rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Spontaneous and evoked angiotensin II sniffer cell activity in the lamina terminalis in vitro.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Pulmonary Vascular Responses to Chronic Intermittent Hypoxia in a Guinea Pig Model of Obstructive Sleep Apnea.International journal of molecular sciences · 2024Article
- Possible Molecular Mechanisms of Hypertension Induced by Sleep Apnea Syndrome/Intermittent Hypoxia.Life (Basel, Switzerland) · 2024Review
- Kidney Renin Release under Hypoxia and Its Potential Link with Nitric Oxide: A Narrative Review.Biomedicines · 2023Review
- Article
- AT1a-dependent GABAAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Carotid body chemoreceptors: physiology, pathology, and implications for health and disease.Physiological reviews · 2021Review
- Role of angiotensin II in chronic intermittent hypoxia-induced hypertension and cognitive decline.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Review
- Anatomical Organization of the Rat Subfornical Organ.Frontiers in cellular neuroscience · 2021Article
- Brain angiotensin converting enzyme-2 in central cardiovascular regulation.Clinical science (London, England : 1979) · 2020Review
- Caspase lesions of PVN-projecting MnPO neurons block the sustained component of CIH-induced hypertension in adult male rats.American journal of physiology. Heart and circulatory physiology · 2020Article
- Angiotensin II-Type I Receptor Antagonism Does Not Influence the Chemoreceptor Reflex or Hypoxia-Induced Central Sleep Apnea in Men.Frontiers in neuroscience · 2020Article
- Potential Contribution of Carotid Body-Induced Sympathetic and Renin-Angiotensin System Overflow to Pulmonary Hypertension in Intermittent Hypoxia.Current hypertension reports · 2019Review
- Could Adjunctive Pharmacology Mitigate Cardiovascular Consequences of Obstructive Sleep Apnea?American journal of respiratory and critical care medicine · 2019Article
- Sniffer cells for the detection of neural Angiotensin II in vitro.Scientific reports · 2019Article
- Angiotensin type 1a receptors in the median preoptic nucleus support intermittent hypoxia-induced hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?Frontiers in physiology · 2019Review
- ATAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sleep apnea is associated with hypertension. The mechanisms contributing to a sustained increase in mean arterial pressure (MAP) even during normoxic awake-state remain unknown. Rats exposed to chronic intermittent hypoxia for 7 days, a model of the hypoxemia associated with sleep apnea, exhibit sustained increases in MAP even during the normoxic dark phase. Activation of the renin-angiotensin system (RAS) has been implicated in chronic intermittent hypoxia (CIH) hypertension. Since the subfornical organ (SFO) serves as a primary target for the central actions of circulating ANG II, we tested the effects of ANG II type 1a receptor (AT1aR) knockdown in the SFO on the sustained increase in MAP in this CIH model. Adeno-associated virus carrying green fluorescent protein (GFP) and small-hairpin RNA against either AT1aR or a scrambled control sequence (SCM) was stereotaxically injected in the SFO of rats. After recovery, MAP, heart rate, respiratory rate, and activity were continuously recorded using radiotelemetry. In the normoxic groups, the recorded variables did not deviate from the baseline values. Both CIH groups exhibited significant increases in MAP during CIH exposures (P < 0.05). During the normoxic dark phase in the CIH groups, only the SCM-injected group exhibited a sustained increase in MAP (P < 0.05). The AT1aR-CIH group showed significant decreases in FosB/ΔFosB staining in the median preoptic nucleus and the paraventricular nuclei of the hypothalamus compared with the SCM-CIH group. Our data indicate that AT1aRs in the SFO are critical for the sustained elevation in MAP and increased FosB/ΔFosB expression in forebrain autonomic nuclei associated with CIH.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.