ArticleSurgical endoscopy2015
Laparoscopic surgery minimizes the release of circulating tumor cells compared to open surgery for hepatocellular carcinoma.
Article in Surgical endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- [Evidence of minimally invasive oncological surgery of the liver].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Pooled it
- Anterior Approach to Improve the Prognosis in HCC Patients Via Decreasing Dissemination of EpCAMJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Trial
- Clinical and biological impact of conversion on outcomes of minimally invasive liver surgery: a multimodal analysis.Updates in surgery · 2026Article
- Review
- Minimally invasive versus open liver resection for hepatocellular carcinoma with microvascular invasion: a propensity score-matching study.Surgical endoscopy · 2025Article
- Exploring Circulating Tumor Cells: Detection Methods and Biomarkers for Clinical Evaluation in Hepatocellular Carcinoma.Journal of clinical and translational hepatology · 2024Review
- Comparison of clinical outcome between laparoscopic and open hepatectomy of high difficulty score for hepatocellular carcinoma: a propensity score analysis.Surgical endoscopy · 2024Article
- Hepatocellular Carcinoma: Surgical Management and Evolving Therapies.Cancer treatment and research · 2024Review
- Radiofrequency ablation induces tumor cell dissemination in a mouse model of hepatocellular carcinoma.European radiology experimental · 2023Article
- Review
- Interleukin-6 in Hepatocellular Carcinoma: A Dualistic Point of View.Biomedicines · 2023Review
- Caudodorsal approach combined with in situ split for laparoscopic right posterior sectionectomy.Surgical endoscopy · 2023Article
- Effect of various hepatectomy procedures on circulating tumor cells in postoperative patients: a case-matched comparative study.Frontiers in medicine · 2023Article
- Assessment for the minimal invasiveness of laparoscopic liver resection by interleukin-6 and thrombospondin-1.World journal of hepatology · 2022Article
- Totally laparoscopic anatomic S7 segmentectomy using in situ split along the right intersectoral and intersegmental planes.Surgical endoscopy · 2021Article
- Impact of anesthesia methods on perioperative systemic inflammation and long-term outcomes in patients undergoing surgery for hepatocellular carcinoma: a propensity score-matched analysis.Annals of translational medicine · 2021Article
- Role of Phenotypes of Circulating Tumor Cells in the Diagnosis and Treatment of Colorectal Cancer.Cancer management and research · 2021Article
- Self-seeding circulating tumor cells promote the proliferation and metastasis of human osteosarcoma by upregulating interleukin-8.Cell death & disease · 2019Article
- Distinct Chemokine Dynamics in Early Postoperative Period after Open and Robotic Colorectal Surgery.Journal of clinical medicine · 2019Article
- Serum Inflammatory Cytokines Comparison in Gastric Cancer Therapy.Open medicine (Warsaw, Poland) · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to determine whether tumor manipulation enhances cancer cell release from the primary tumor in HCC patients and which surgical approach, open surgery or laparoscopic resection, is superior with respect to preventing tumor cells from scattering in the blood.
methodsA total of 26 HCC patients were prospectively randomized to receive either open surgery (n = 14) or laparoscopic surgery (n = 12). Blood samples were obtained at three time points: preoperative, postoperative, and 24 h after surgery. The CD45(-)/CD44(+)/CD90(+) cells were obtained and counted using quantitative flow cytometry. The serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor (TNF-α) were also compared between the two groups.
resultsThere was no significant difference between the laparoscopic and open groups in terms of patient characteristics. The levels of CCSCs increased immediately after surgical manipulation, and the laparoscopy group released fewer tumor cells into the blood stream. The amount of CCSCs in both groups decreased to reach a similar level 24 h after surgery. Both IL-6 and IL-8 increased after surgery, and the mean postoperative increases in IL-6 and IL-8 serum levels were significantly less in the laparoscopic group than in the open group. The TNF-α levels showed no differences at any time point.
conclusionsOur results showed that patients with laparoscopic surgery have lower IL-6, IL-8 secretion and less CTCs, which may suggest an advantage by restricting CTCs release and a preserved immune response. Further studies are needed to investigate the relationship between the number of CCSCs after surgery and long-term survival rates.
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