ArticleBMC genomics2014
The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Research progress into the principles and methods underlying capsular typing of Glaesserella parasuis.Veterinary research · 2024Pooled it
- Global whole-genome, phylodynamic, and machine-learning analysis ofApplied and environmental microbiology · 2026Article
- Evidence for Genotype-Associated Differences in Disease Severity and Limitations of Serotype-Based Classification inPathogens (Basel, Switzerland) · 2026Article
- Article
- A Triplex Real-Time PCR Assay for Simultaneous Detection ofTransboundary and emerging diseases · 2026Article
- Isolation and identification of two highly virulent Glaesserella parasuis serovar 7 strains in China.BMC microbiology · 2025Article
- Pathotyping and molecular serotyping of clinical isolates of Glaesserella parasuis in Taiwan.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Capsular immunity is necessary for protection against some but not all strains of Glaesserella parasuis.Veterinary microbiology · 2025Article
- Molecular Characterization and Phylogenetic Analysis ofPathogens (Basel, Switzerland) · 2023Article
- Pan-genome wide association study ofFrontiers in microbiology · 2023Article
- Identification ofPathogens (Basel, Switzerland) · 2022Article
- Genome-Wide Association Studies for the Detection of Genetic Variants Associated With Daptomycin and Ceftaroline Resistance inFrontiers in microbiology · 2021Article
- Comparison of theFrontiers in veterinary science · 2021Article
- Serotyping and pathotyping of Glaesserella parasuis isolated 2012-2019 in Germany comparing different PCR-based methods.Veterinary research · 2020Article
- Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism.Communications biology · 2020Article
- Evaluation of the recombinant proteins RlpB and VacJ as a vaccine for protection against Glaesserella parasuis in pigs.BMC veterinary research · 2020Article
- Generation and Evaluation of a Glaesserella (Haemophilus) parasuis Capsular Mutant.Infection and immunity · 2020Article
- Whole-genome sequence analyses ofPeerJ · 2020Article
- Transcriptomic differences noted in Glaesserella parasuis between growth in broth and on agar.PloS one · 2019Article
- Association betweenPeerJ · 2019Article
Corrections and comments
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Authors and funding
19 authors at 9 institutions in 3 countries.
Funding
Abstract
backgroundHaemophilus parasuis is the etiologic agent of Glässer's disease in pigs and causes devastating losses to the farming industry. Whilst some hyper-virulent isolates have been described, the relationship between genetics and disease outcome has been only partially established. In particular, there is weak correlation between serovar and disease phenotype. We sequenced the genomes of 212 isolates of H. parasuis and have used this to describe the pan-genome and to correlate this with clinical and carrier status, as well as with serotype.
resultsRecombination and population structure analyses identified five groups with very high rates of recombination, separated into two clades of H. parasuis with no signs of recombination between them. We used genome-wide association methods including discriminant analysis of principal components (DAPC) and generalised linear modelling (glm) to look for genetic determinants of this population partition, serovar and pathogenicity. We were able to identify genes from the accessory genome that were significantly associated with phenotypes such as potential serovar specific genes including capsule genes, and 48 putative virulence factors that were significantly different between the clinical and non-clinical isolates. We also show that the presence of many previously suggested virulence factors is not an appropriate marker of virulence.
conclusionsThese genes will inform the generation of new molecular diagnostics and vaccines, and refinement of existing typing schemes and show the importance of the accessory genome of a diverse species when investigating the relationship between genotypes and phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.