ArticleThe international journal of neuropsychopharmacology2014
Oxytocin reduces cocaine seeking and reverses chronic cocaine-induced changes in glutamate receptor function.
Article in The international journal of neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- The oxytocin system mediates behavioral and neurobiological alterations associated with early adversity.Molecular psychiatry · 2026Article
- Effects of systemic oxytocin receptor activation and blockade on risky decision making in female and male rats.Behavioral neuroscience · 2025Article
- Oxytocin Attenuates the Endocrine Disrupting Effects of Cocaine in the Female Rat.Endocrinology · 2025Article
- Emerging medications and pharmacological treatment approaches for substance use disorders.Pharmacology, biochemistry, and behavior · 2025Review
- Sex differences in stress-modulated cocaine vulnerability: female rodents are more sensitive to the effects of stress exposure at different developmental stages.Frontiers in behavioral neuroscience · 2025Review
- Contrasting Effects of Oxytocin on MK801-Induced Social and Non-Social Behavior Impairment and Hyperactivity in a Genetic Rat Model of Schizophrenia-Linked Features.Brain sciences · 2024Article
- Cocaine use disorder patients develop distinct patterns of regulation of acth secretion by a vasopressin agonist and oxytocin: Report on a laboratory study.Drug and alcohol dependence reports · 2023Article
- Abstinence from Escalation of Cocaine Intake Changes the microRNA Landscape in the Cortico-Accumbal Pathway.Biomedicines · 2023Article
- The Role of Oxytocin and Vasopressin in Drug-Induced Reward-Implications for Social and Non-Social Factors.Biomolecules · 2023Review
- Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking.Translational psychiatry · 2022Article
- Peer-induced cocaine seeking in rats: Comparison to nonsocial stimuli and role of paraventricular hypothalamic oxytocin neurons.Addiction biology · 2022Article
- Intranasal oxytocin may improve odds of abstinence in cocaine-dependent patients: results from a preliminary study.Drug and alcohol dependence reports · 2022Article
- Oxytocin and Addiction: Potential Glutamatergic Mechanisms.International journal of molecular sciences · 2021Review
- Neural mechanisms underlying incubation of methamphetamine craving: A mini-review.Pharmacology, biochemistry, and behavior · 2020Review
- Oxytocin Attenuates Expression, but Not Acquisition, of Sucrose Conditioned Place Preference in Rats.Frontiers in behavioral neuroscience · 2020Article
- Neural correlates of oxytocin and cue reactivity in cocaine-dependent men and women with and without childhood trauma.Psychopharmacology · 2019Article
- Brain and Cognition for Addiction Medicine: From Prevention to Recovery Neural Substrates for Treatment of Psychostimulant-Induced Cognitive Deficits.Frontiers in psychiatry · 2019Review
- Attenuated cocaine-seeking after oxytocin administration in male and female rats.Psychopharmacology · 2018Article
- Regionally Specific Effects of Oxytocin on Reinstatement of Cocaine Seeking in Male and Female Rats.The international journal of neuropsychopharmacology · 2018Article
- Decreased Blood Levels of Oxytocin in Ketamine-Dependent Patients During Early Abstinence.Frontiers in psychiatry · 2018Article
Corrections and comments
- Erratum issuedErratum.2016
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOxytocin, a neurohypophyseal neuropeptide, is a potential mediator and regulator of drug addiction. However, the cellular mechanisms of oxytocin in drug seeking remain unknown.
methodsIn the present study, we used a self-administration/reinstatement model to study the effects of oxytocin on cocaine seeking and its potential interaction with glutamate function at the receptor level.
resultsSystemic oxytocin dose-dependently reduced cocaine self-administration during various schedules of reinforcement, including fixed ratio 1, fixed ratio 5, and progressive ratio. Oxytocin also attenuated reinstatement to cocaine seeking induced by cocaine prime or conditioned cues. Western-blot analysis indicated that oxytocin increased phosphorylation of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunit at the Ser 845 site with or without accompanying increases in phosphorylation of extracellular signal-regulated kinase, in several brain regions, including the prefrontal cortex, bed nucleus of the stria terminalis, amygdala, and dorsal hippocampus. Immunoprecipitation of oxytocin receptor and GluA1 subunit receptors further demonstrated a physical interaction between these 2 receptors, although the interaction was not influenced by chronic cocaine or oxytocin treatment. Oxytocin also attenuated sucrose seeking in a GluA1- or extracellular-signal-regulated kinase-independent manner.
conclusionsThese findings suggest that oxytocin mediates cocaine seeking through interacting with glutamate receptor systems via second messenger cascades in mesocorticolimbic regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.