Evidence map›Paper›PMID 25539257›Full record

ArticleAJR. American journal of roentgenology2015

Microwave ablation of hepatic tumors abutting the diaphragm is safe and effective.

Amanda R Smolock, Meghan G Lubner, Timothy J Ziemlewicz, J Louis Hinshaw, Douglas R Kitchin, Christopher L Brace, Fred T Lee

Open access · greenAbstract read
In one paragraph

Article in AJR. American journal of roentgenology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  16. Hepatic Microwave Ablation in Challenging Locations.Seminars in interventional radiology · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Amanda R Smolock1 Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, MC 3252, Madison, WI 53792.
Meghan G Lubner
Timothy J Ziemlewicz
J Louis Hinshaw
Douglas R Kitchin
Christopher L Brace
Fred T Lee
University of Wisconsin–Madison · US

Funding

Optimizing microwave ablation techniques for targeted cancer therapyR01CA142737 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BRACE, CHRISTOPHER L · 2010 to 2013
$1.2M
Periodic Contrast-Enhanced CT With HYPR Reconstruction For Ablation MonitoringR01CA149379 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BRACE, CHRISTOPHER L · 2010 to 2014
$1.2M
NCI NIH HHS R01 CA142737NCI NIH HHS R01 CA149379
6 · The paper itself

Abstract

objectiveThe purpose of this study was to evaluate the incidence of clinically significant diaphragmatic injuries and local tumor progression after microwave ablation of hepatic tumors abutting the diaphragm. MATERIALS AND

methodsThis retrospective study included 55 peripheral hepatic tumors abutting the diaphragm treated by microwave ablation versus a control group of 15 centrally located tumors. Treated tumors were further subdivided according to the use of artificial ascites (fluid vs no fluid) and whether instilled fluid achieved displacement of the liver surface away from the diaphragm (displaced vs nondisplaced). Measurements of tumor size, distance to the diaphragm, ablation zone size, displacement distance, length of the ablation zone along the liver capsule, diaphragm thickness, diaphragmatic hernia, and local tumor progression were made on pre- and postablation CT and MRI. The electronic medical record was reviewed for patient self-reported pain scores and other symptoms. Data were analyzed by use of the Kruskal-Wallis and Fisher exact tests.

resultsThere were no cases of diaphragmatic hernia in peripheral or central tumors. Postablation diaphragm thickness was higher in peripheral hepatic tumors than in control tumors. Peripheral tumors had an overall higher incidence of postprocedure shoulder pain (18% vs 0%) and local tumor progression (5.5% vs 0%) compared with control tumors, but these differences did not achieve statistical significance (p = 0.2 and p = 1, respectively).

conclusionOur study shows that microwave ablation of peridiaphragmatic hepatic tumors is safe, without incidence of diaphragmatic hernia, and can be performed with a low rate of local tumor progression.

Indexed as

Catheter AblationFemaleHernia, DiaphragmaticHumansLiver NeoplasmsMaleMicrowavesMiddle AgedRadiographyRetrospective StudiesTreatment Outcomeablationdiaphragmmicrowaveperipheral

Identifiers

PMID25539257
PMCPMC6560625
OpenAlexW2095094366

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.