ArticleAdvanced biomedical research2014
Effects of biosurfactant produced by Lactobacillus casei on gtfB, gtfC, and ftf gene expression level in S. mutans by real-time RT-PCR.
Article in Advanced biomedical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Postbiotics and Dental Caries: A Systematic Review.Clinical and experimental dental research · 2025Pooled it
- Potential of microbial-derived biosurfactants for oral applications-a systematic review.BMC oral health · 2024Pooled it
- Understanding The Role of Lacticaseibacillus rhamnosus in Vaginal Dysbiosis: in Vitro Studies and Clinical Evidence.Probiotics and antimicrobial proteins · 2026Review
- The strategic role of biotics in dental caries prevention: A scoping review.Food science & nutrition · 2024Article
- Inhibitory effect of helium cold atmospheric plasma on cariogenic biofilms.Journal of oral microbiology · 2024Article
- Postbiotic Metabolite ofPharmaceutics · 2023Article
- Inhibition of Streptococcus mutans Biofilm Formation by the Joint Action of Oxyresveratrol and Lactobacillus casei.Applied and environmental microbiology · 2022Article
- Identification of the effects of acid-resistantIranian journal of basic medical sciences · 2021Article
- Lactobacilli as Anti-biofilm Strategy in Oral Infectious Diseases: A Mini-Review.Frontiers in medical technology · 2021Review
- Lactobacillus Plantarum 108 Inhibits Streptococcus mutans and Candida albicans Mixed-Species Biofilm Formation.Antibiotics (Basel, Switzerland) · 2020Article
- Suppressive Effects of Hainosan (Painongsan) against Biofilm Production byDentistry journal · 2020Article
- Probiotic Lactobacillus sp. inhibit growth, biofilm formation and gene expression of caries-inducing Streptococcus mutans.Journal of cellular and molecular medicine · 2018Article
- Prevention of Cross-contamination Risk by Disinfection of Irreversible Hydrocolloid Impression Materials with Ozonated Water.International journal of preventive medicine · 2018Article
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Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Streptococci are the pioneer strains in plaque formation and Streptococcus mutans are the main etiological agent of dental plaque and caries. In general, biofilm formation is a step-wise process, which begins by adhesion of planktonic cells to the surfaces. Evidences show that expression of glucosyltransferase B and C (gtfB and gtfC) and fructosyltransferase (ftf) genes play critical role in initial adhesion of S. mutans to the tooth surface which results in formation of dental plaques and consequently caries and other periodontal disease. MATERIALS AND
methodsThe aim of this study was to determine the effect of biosurfactants produced by a probiotic strain; Lactobacillus casei (ATCC39392) on gene expression profile of gftB/C and tft of S. mutans (ATCC35668) using quantitative real-time PCR.
resultsThe application of the prepared biosurfactant caused dramatic down regulation of all the three genes under study. The reduction in gene expression was statistically highly significant (for gtfB, P > 0.0002; for gtfC, P > 0.0063, and for ftf, P > 0.0057).
conclusionConsiderable downregulation of all three genes in the presence of the prepared biosurfactant comparing to untreated controls is indicative of successful inhibition of influential genes in bacterial adhesion phenomena. In view of the importance of glucosyltransferase gene products for S.mutans attachment to the tooth surface which is the initial important step in biofilm production and dental caries, further research in this field may lead to an applicable alternative for successful with least adverse side effects in dental caries prevention.
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