ArticlePeerJ2014
Arterial spin labeling versus BOLD in direct challenge and drug-task interaction pharmacological fMRI.
Article in PeerJ, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Investigating the effect of increased dopamine signaling on cerebral blood flow in Major Depressive Disorder: a double-blind randomized placebo-controlled study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Region- and time- specific effects of ketamine on cerebral blood flow: a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Investigating resting brain perfusion abnormalities and disease target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls.Translational psychiatry · 2020Trial
- Resting-state brain function and its modulation by intranasal oxytocin in antisocial personality disorder with and without psychopathy.Scientific reports · 2026Article
- Pharmacological manipulation of neurotransmitter activity induces disparate effects on cerebral blood flow and resting-state fluctuations.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Specificity of Quantitative Functional Brain Mapping with Arterial Spin-Labeling for Preoperative Assessment.AJNR. American journal of neuroradiology · 2023Article
- Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment.Alcohol, clinical & experimental research · 2023Article
- Identification of resting-state networks using dynamic brain perfusion SPECT imaging: A fSPECT case report.Frontiers in human neuroscience · 2023Article
- Lessons learned from using fMRI in the early clinical development of a mu-opioid receptor antagonist for disorders of compulsive consumption.Psychopharmacology · 2021Review
- The New Tics study: A Novel Approach to Pathophysiology and Cause of Tic Disorders.Journal of psychiatry and brain science · 2020Article
- Dopamine Buffering Capacity Imaging: A Pharmacodynamic fMRI Method for Staging Parkinson Disease.Frontiers in neurology · 2020Article
- Ketamine induced changes in regional cerebral blood flow, interregional connectivity patterns, and glutamate metabolism.Journal of psychiatric research · 2019Article
- A short, robust brain activation control task optimised for pharmacological fMRI studies.PeerJ · 2018Article
- Brain Magnetic Resonance Imaging (MRI) as a Potential Biomarker for Parkinson's Disease (PD).Brain sciences · 2017Review
- Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging.PeerJ · 2015Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A carefully controlled study allowed us to compare the sensitivity of ASL (arterial spin labeling) and BOLD (blood oxygen level dependent) fMRI for detecting the effects of the adenosine A2a antagonist tozadenant in Parkinson disease. The study compared the effect of drug directly or the interaction of the drug with a cognitive task. Only ASL detected the direct effect of tozadenant. BOLD was more sensitive to the cognitive task, which (unlike most drugs) allows on-off comparisons over short periods of time. Neither ASL nor BOLD could detect a cognitive-pharmacological interaction. These results are consistent with the known relative advantages of each fMRI method, and suggest that for drug development, directly imaging pharmacodynamic effects with ASL may have advantages over cognitive-pharmacological interaction BOLD, which has hitherto been the more common approach to pharmacological fMRI.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.