Evidence map›Paper›PMID 25538793›Full record

ArticleMolecular cytogenetics2014

Genes on B chromosomes of vertebrates.

Alexey I Makunin, Polina V Dementyeva, Alexander S Graphodatsky, Vitaly T Volobouev, Anna V Kukekova, Vladimir A Trifonov

Open access · goldAbstract read
In one paragraph

Article in Molecular cytogenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. B Chromosomes' Sequences in Yellow-Necked MiceLife (Basel, Switzerland) · 2021
    Article
  5. B Chromosomes in Free-Living Flatworms of the GenusInternational journal of molecular sciences · 2021
    Article
  6. Review
  7. Origin of a Giant Sex Chromosome.Molecular biology and evolution · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Alexey I MakuninInstitute of Molecular and Cellular Biology SВ RAS, Novosibirsk, 630090 Russia ; Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, St. Petersburg, Russia.
Polina V DementyevaInstitute of Molecular and Cellular Biology SВ RAS, Novosibirsk, 630090 Russia.
Alexander S GraphodatskyInstitute of Molecular and Cellular Biology SВ RAS, Novosibirsk, 630090 Russia ; Novosibirsk State University, Novosibirsk, Russia.
Vitaly T VolobouevMuseum National d'Histoire Naturelle, Origine, Structure et Evolution de la Biodiversite, Paris, France.
Anna V KukekovaDepartment of Animal Sciences, The University of Illinois at Urbana-Champaign, Champaign, USA.
Vladimir A TrifonovInstitute of Molecular and Cellular Biology SВ RAS, Novosibirsk, 630090 Russia ; Novosibirsk State University, Novosibirsk, Russia.
Institute of Molecular and Cell Biology · RUInstitut de Systématique, Évolution, Biodiversité · FRNovosibirsk State University · RUUniversity of Illinois Urbana-Champaign · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a growing body of evidence that B chromosomes, once regarded as totally heterochromatic and genetically inert, harbor multiple segmental duplications containing clusters of ribosomal RNA genes, processed pseudogenes and protein-coding genes. Application of novel molecular approaches further supports complex composition and possible phenotypic effects of B chromosomes.

resultsHere we review recent findings of gene-carrying genomic segments on B chromosomes from different vertebrate groups. We demonstrate that the genetic content of B chromosomes is highly heterogeneous and some B chromosomes contain multiple large duplications derived from various chromosomes of the standard karyotype. Although B chromosomes seem to be mostly homologous to each other within a species, their genetic content differs between species. There are indications that some genomic regions are more likely to be located on B chromosomes.

conclusionsThe discovery of multiple autosomal genes on B chromosomes opens a new discussion about their possible effects ranging from sex determination to fitness and adaptation, their complex interactions with host genome and role in evolution.

Indexed as

B chromosomesEvolution of genomesProto-oncogenesSegmental duplicationVertebrates

Identifiers

PMID25538793
PMCPMC4274688
OpenAlexW2129892332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.