Evidence map›Paper›PMID 25538682›Full record

ReviewFrontiers in endocrinology2014

RFamide Peptides in Early Vertebrate Development.

Guro Katrine Sandvik, Kjetil Hodne, Trude Marie Haug, Kataaki Okubo, Finn-Arne Weltzien

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  6. Review
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  11. QRFP and Its Receptors Regulate Locomotor Activity and Sleep in Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Guro Katrine SandvikDepartment of Basic Sciences and Aquatic medicine, Norwegian University of Life Sciences , Oslo , Norway.
Kjetil HodneInstitute for Experimental Medical Research, Oslo University Hospital , Oslo , Norway.
Trude Marie HaugDepartment of Biosciences, University of Oslo , Oslo , Norway.
Kataaki OkuboDepartment of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo , Japan.
Finn-Arne WeltzienDepartment of Basic Sciences and Aquatic medicine, Norwegian University of Life Sciences , Oslo , Norway.
Norwegian University of Life Sciences · NOInstitutt for Eksperimentell Medisinsk Forskning · NOThe University of Tokyo · JPUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RFamides (RFa) are neuropeptides involved in many different physiological processes in vertebrates, such as reproductive behavior, pubertal activation of the reproductive endocrine axis, control of feeding behavior, and pain modulation. As research has focused mostly on their role in adult vertebrates, the possible roles of these peptides during development are poorly understood. However, the few studies that exist show that RFa are expressed early in development in different vertebrate classes, perhaps mostly associated with the central nervous system. Interestingly, the related peptide family of FMRFa has been shown to be important for brain development in invertebrates. In a teleost, the Japanese medaka, knockdown of genes in the Kiss system indicates that Kiss ligands and receptors are vital for brain development, but few other functional studies exist. Here, we review the literature of RFa in early vertebrate development, including the possible functional roles these peptides may play.

Indexed as

26RFa/QRFPbrain developmentearly developmentGnIHKissNPFFPrRPRFa

Identifiers

PMID25538682
PMCPMC4255600
OpenAlexW2143631045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.