ArticleFrontiers in endocrinology2014
Proteomic Analysis of Pig (Sus scrofa) Olfactory Soluble Proteome Reveals O-Linked-N-Acetylglucosaminylation of Secreted Odorant-Binding Proteins.
Article in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- How allosteric mutations control ligand binding in Lipocalin protein: odorant binding protein as a test case.Cellular and molecular life sciences : CMLS · 2025Article
- Article
- Pheromones, binding proteins, and olfactory systems in the pig (Frontiers in veterinary science · 2022Review
- Interpretive review: Semiochemicals in domestic pigs and dogs.Frontiers in veterinary science · 2022Review
- Variation of ewe olfactory secretome during a ram effect.Frontiers in veterinary science · 2022Article
- Odorant-binding proteins in canine anal sac glands indicate an evolutionarily conserved role in mammalian chemical communication.BMC ecology and evolution · 2021Article
- Aberrant RL2 O-GlcNAc antibody reactivity against serum-IgA1 of patients with colorectal cancer.Glycoconjugate journal · 2021Article
- Biological Roles of Lipocalins in Chemical Communication, Reproduction, and Regulation of Microbiota.Frontiers in physiology · 2021Review
- Identification of potential chemosignals in the European water vole Arvicola terrestris.Scientific reports · 2019Article
- The olfactory secretome varies according to season in female sheep and goat.BMC genomics · 2019Article
- The Many Ways by WhichMolecules (Basel, Switzerland) · 2018Review
- Odorant-Binding Proteins as Sensing Elements for Odour Monitoring.Sensors (Basel, Switzerland) · 2018Review
- Binding Specificity of Native Odorant-Binding Protein Isoforms Is Driven by Phosphorylation andFrontiers in endocrinology · 2018Article
- Involvement of O-GlcNAcylation in the Skeletal Muscle Physiology and Physiopathology: Focus on Muscle Metabolism.Frontiers in endocrinology · 2018Review
- Reverse chemical ecology: Olfactory proteins from the giant panda and their interactions with putative pheromones and bamboo volatiles.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- On the tear proteome of the house mouse (PeerJ · 2017Article
- On the saliva proteome of the Eastern European house mouse (Mus musculus musculus) focusing on sexual signalling and immunity.Scientific reports · 2016Article
- The Pig Olfactory Brain: A Primer.Chemical senses · 2016Article
- 30 Years Old: O-GlcNAc Reaches the Age of Reason - Regulation of Cell Signaling and Metabolism by O-GlcNAcylation.Frontiers in endocrinology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diversity of olfactory binding proteins (OBPs) is a key point to understand their role in molecular olfaction. Since only few different sequences were characterized in each mammalian species, they have been considered as passive carriers of odors and pheromones. We have explored the soluble proteome of pig nasal mucus, taking benefit of the powerful tools of proteomics. Combining two-dimensional electrophoresis, mass spectrometry, and western-blot with specific antibodies, our analyses revealed for the first time that the pig nasal mucus is mainly composed of secreted OBP isoforms, some of them being potentially modified by O-GlcNAcylation. An ortholog gene of the glycosyltransferase responsible of the O-GlcNAc linking on extracellular proteins in Drosophila and Mouse (EOGT) was amplified from tissues of pigs of different ages and sex. The sequence was used in a phylogenetic analysis, which evidenced conservation of EOGT in insect and mammalian models studied in molecular olfaction. Extracellular O-GlcNAcylation of secreted OBPs could finely modulate their binding specificities to odors and pheromones. This constitutes a new mechanism for extracellular signaling by OBPs, suggesting that they act as the first step of odor discrimination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.