ReviewFrontiers in neurology2014
The piriform cortex and human focal epilepsy.
Review in Frontiers in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- Olfactory Testing in Temporal Lobe Epilepsy: a Systematic Review.Current neurology and neuroscience reports · 2020Pooled it
- A Quantitative Meta-analysis of Olfactory Dysfunction in Epilepsy.Neuropsychology review · 2019Pooled it
- No link between piriform cortex subregion resection and seizure freedom in two cohorts with temporal lobe epilepsy.Journal of neurology · 2026Article
- Targeting Neuroinflammation in the Piriform Cortex-Amygdala: Enhanced Efficacy of Niosome-Based Sodium Butyrate in Ischemic Stroke.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Article
- Piriform seizures mediated by the piriform-entorhino-dentate circuit induce brain-wide functional reorganization in mice.PLoS biology · 2026Article
- Effect of low frequency stimulation of olfactory bulb and olfactory epithelium on epileptiform activity and synaptic plasticity following pentylenetetrazol administration in rats.Behavioral and brain functions : BBF · 2026Article
- Evaluation of limbic microstructural abnormalities in temporal lobe epilepsy: A neurite orientation distribution and density imaging study.Epilepsia · 2025Article
- Brain Tumors, AI and Psychiatry: Predicting Tumor-Associated Psychiatric Syndromes with Machine Learning and Biomarkers.International journal of molecular sciences · 2025Review
- The Exchange Breathing Method for Seizure Intervention: A Historical and Scientific Review of Epilepsy and Its Evolving Therapeutic Paradigms.Journal of personalized medicine · 2025Review
- The p.R321C mutation in the p62 protein is associated with abnormalities in the central nervous system.Scientific reports · 2025Article
- Voxel-Based Lesion Symptom Mapping to Predict Poststroke Epilepsy After Mechanical Thrombectomy.European journal of neurology · 2025Article
- Relationship of left piriform cortex network centrality with temporal lobe epilepsy duration and drug resistance.European journal of neurology · 2025Article
- Marked differences in the effects of levetiracetam and its analogue brivaracetam on microglial, astrocytic, and neuronal density in the rat model of kainic acid-induced temporal lobe epilepsy.Frontiers in pharmacology · 2025Article
- The Little-Known Ribbon-Shaped Piriform Cortex: A Key Node in Temporal Lobe Epilepsy-Anatomical Insights and Its Potential for Surgical Treatment.Diagnostics (Basel, Switzerland) · 2024Review
- Posterior Basolateral Amygdala is a Critical Amygdaloid Area for Temporal Lobe Epilepsy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Shifts in the spatiotemporal profile of inflammatory phenotypes of innate immune cells in the rat brain following acute intoxication with the organophosphate diisopropylfluorophosphate.Journal of neuroinflammation · 2024Article
- Olfactory Dysfunction and Limbic Hypoactivation in Temporal Lobe Epilepsy.Human brain mapping · 2024Article
- Adult Case of Pontocerebellar Hypoplasia without the Claustrum.Neurology international · 2024Article
- Interictal blood-brain barrier dysfunction in piriform cortex of people with epilepsy.Annals of clinical and translational neurology · 2024Article
- Connectivity of the Piriform Cortex and its Implications in Temporal Lobe Epilepsy.medRxiv : the preprint server for health sciences · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is surprising that the piriform cortex, when compared to the hippocampus, has been given relatively little significance in human epilepsy. Like the hippocampus, it has a phylogenetically preserved three-layered cortex that is vulnerable to excitotoxic injury, has broad connections to both limbic and cortical areas, and is highly epileptogenic - being critical to the kindling process. The well-known phenomenon of early olfactory auras in temporal lobe epilepsy highlights its clinical relevance in human beings. Perhaps because it is anatomically indistinct and difficult to approach surgically, as it clasps the middle cerebral artery, it has, until now, been understandably neglected. In this review, we emphasize how its unique anatomical and functional properties, as primary olfactory cortex, predispose it to involvement in focal epilepsy. From recent convergent findings in human neuroimaging, clinical epileptology, and experimental animal models, we make the case that the piriform cortex is likely to play a facilitating and amplifying role in human focal epileptogenesis, and may influence progression to epileptic intractability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.