ArticleFrontiers in behavioral neuroscience2014
Variation in the oxytocin receptor gene is associated with behavioral and neural correlates of empathic accuracy.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of neuroimaging studies on pain empathy: investigating the role of visual information and observers' perspective.Social cognitive and affective neuroscience · 2019Pooled it
- Empathy for pain persists across live two-way video interactions and viewing of prerecorded videos.Cognitive, affective & behavioral neuroscience · 2026Article
- Article
- Article
- Screening of disease-related biomarkers related to neuropathic pain (NP) after spinal cord injury (SCI).Human genomics · 2021Article
- Functional Polymorphisms in Oxytocin and Dopamine Pathway Genes and the Development of Dispositional Compassion Over Time: The Young Finns Study.Frontiers in psychology · 2021Article
- Oxytocin receptor gene variants are associated with emotion recognition and resilience, but not with false-belief reasoning performance in healthy young Korean volunteers.CNS neuroscience & therapeutics · 2019Article
- Affective Language, Interpretation Bias and Its Molecular Genetic Variations: Exploring the Relationship Between Genetic Variations of the OXTR Gene (rs53576 and rs2268498) and the Emotional Evaluation of Words Related to the Self or the Other.Frontiers in psychology · 2019Article
- The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism.Molecular autism · 2019Article
- Change in Objective Measure of Empathic Accuracy Following Social Cognitive Training.Frontiers in psychiatry · 2019Article
- Emotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2.Social cognitive and affective neuroscience · 2018Article
- The association of childhood maltreatment with depression and anxiety is not moderated by the oxytocin receptor gene.European archives of psychiatry and clinical neuroscience · 2017Article
- Imaging genetics in neurodevelopmental psychopathology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience.Neuroscience and biobehavioral reviews · 2017Review
- Microsatellite Polymorphisms Adjacent to the Oxytocin Receptor Gene in Domestic Cats: Association with Personality?Frontiers in psychology · 2017Article
- Antisocial behavior and polymorphisms in the oxytocin receptor gene: findings in two independent samples.Molecular psychiatry · 2016Article
- Oxytocin and parent-child interaction in the development of empathy among children at risk for autism.Developmental psychology · 2016Article
- Article
- A Precision Medicine Approach to Oxytocin Trials.Current topics in behavioral neurosciencesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuromodulators oxytocin and serotonin have been implicated in regulating affective processes underlying empathy. Understanding this dependency, however, has been limited by a lack of objective metrics for measuring empathic performance. Here we employ a novel psychophysical method for measuring empathic performance that quantitatively measures the ability of subjects to decode the experience of another person's pain. In 50 female subjects, we acquired functional magnetic resonance imaging data as they were exposed to a target subject experiencing variable degrees of pain, whilst performing an irrelevant attention-demanding task. We investigated the effect of variation in the oxytocin receptor gene (OXTR) and the serotonin transporter gene (SLC6A4) on the psychophysical and neurometric variability associated with empathic performance. The OXTR rs2268498 and rs53576 polymorphisms, but not the SLC6A4 5-HTTLPR, were associated with significant differences in empathic accuracy, with CC- and AA-carriers, respectively, displaying higher empathic accuracy. For OXTR rs2268498 there was also a genotype difference in the correlation between empathic accuracy and activity in the superior temporal sulcus (STS). In OXTR rs2268498 CC-carriers, high empathic accuracy was associated with stronger responsiveness of the right STS to the observed pain. Together, the results show that genetic variation in the OXTR has significant influence on empathic accuracy and that this may be linked to variable responsivity of the STS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.