ReviewFrontiers in cellular neuroscience2014
Convergence of circuit dysfunction in ASD: a common bridge between diverse genetic and environmental risk factors and common clinical electrophysiology.
Review in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Tsc1 deletion in Purkinje neurons disrupts the axon initial segment, impairing excitability and cerebellar function.Neurobiology of disease · 2025Article
- Article
- Parsing evoked and induced gamma response differences in Autism: A visual evoked potential study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Pilot Study of Personalized Transcranial Magnetic Stimulation with Spectral Electroencephalogram Analyses for Assessing and Treating Persons with Autism.Journal of personalized medicine · 2024Article
- Dopamine Dysregulation in Reward and Autism Spectrum Disorder.Brain sciences · 2024Review
- Cerebellar contribution to autism-relevant behaviors in fragile X syndrome models.Cell reports · 2023Article
- Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice.Nature communications · 2021Article
- Multivariate Neural Connectivity Patterns in Early Infancy Predict Later Autism Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Excitation/Inhibition Modulators in Autism Spectrum Disorder: Current Clinical Research.Frontiers in neuroscience · 2021Review
- Day-to-Day Test-Retest Reliability of EEG Profiles in Children With Autism Spectrum Disorder and Typical Development.Frontiers in integrative neuroscience · 2020Article
- Revisiting the excitation/inhibition imbalance hypothesis of ASD through a clinical lens.The British journal of radiology · 2019Review
- Parvalbumin Cell Ablation of NMDA-R1 Leads to Altered Phase, But Not Amplitude, of Gamma-Band Cross-Frequency Coupling.Brain connectivity · 2019Article
- A MEG Study of Acute Arbaclofen (STX-209) Administration.Frontiers in integrative neuroscience · 2019Article
- Modeling of Autism Using Organoid Technology.Molecular neurobiology · 2017Review
- A Stem Cell Model of the Motor Circuit Uncouples Motor Neuron Death from Hyperexcitability Induced by SMN Deficiency.Cell reports · 2016Article
- Cellular and circuit models of increased resting-state network gamma activity in schizophrenia.Neuroscience · 2016Review
- Annual Research Review: Discovery science strategies in studies of the pathophysiology of child and adolescent psychiatric disorders--promises and limitations.Journal of child psychology and psychiatry, and allied disciplines · 2016Review
- Resting-State Functional Connectivity in Autism Spectrum Disorders: A Review.Frontiers in psychiatry · 2016Review
- Maturation of auditory neural processes in autism spectrum disorder - A longitudinal MEG study.NeuroImage. Clinical · 2016Article
- Inhibition-Based Biomarkers for Autism Spectrum Disorder.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Most recent estimates indicate that 1 in 68 children are affected by an autism spectrum disorder (ASD). Though decades of research have uncovered much about these disorders, the pathological mechanism remains unknown. Hampering efforts is the seeming inability to integrate findings over the micro to macro scales of study, from changes in molecular, synaptic and cellular function to large-scale brain dysfunction impacting sensory, communicative, motor and cognitive activity. In this review, we describe how studies focusing on neuronal circuit function provide unique context for identifying common neurobiological disease mechanisms of ASD. We discuss how recent EEG and MEG studies in subjects with ASD have repeatedly shown alterations in ensemble population recordings (both in simple evoked related potential latencies and specific frequency subcomponents). Because these disease-associated electrophysiological abnormalities have been recapitulated in rodent models, studying circuit differences in these models may provide access to abnormal circuit function found in ASD. We then identify emerging in vivo and ex vivo techniques, focusing on how these assays can characterize circuit level dysfunction and determine if these abnormalities underlie abnormal clinical electrophysiology. Such circuit level study in animal models may help us understand how diverse genetic and environmental risks can produce a common set of EEG, MEG and anatomical abnormalities found in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.