Evidence map›Paper›PMID 25538470›Full record

ArticleJournal of basic and clinical pharmacy2014

In vitro antibacterial activity of Camellia sinensis extract against cariogenic microorganisms.

P Anita, Shyam Sivasamy, P D Madan Kumar, I Nanda Balan, Sumathi Ethiraj

Abstract read
In one paragraph

Article in Journal of basic and clinical pharmacy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 105 citations in OpenAlex.

  1. Article
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  3. Review
  4. Dual effects ofNarra J · 2025
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  8. Expanded Therapeutic Applications ofCombinatorial chemistry & high throughput screening · 2024
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  9. Article
  10. Anti-Inflammatory and Anti-Quorum Sensing Effect ofCurrent issues in molecular biology · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Antibacterial efficacy of ethanolic extract ofJournal of advanced veterinary and animal research · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. An In vitro Study to Compare the Effect of Different Types of Tea with Chlorhexidine onJournal of clinical and diagnostic research : JCDR · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

P AnitaDepartment of Public Health Dentistry, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India.
Shyam SivasamyDepartment of Public Health Dentistry, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India.
P D Madan KumarDepartment of Public Health Dentistry, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India.
I Nanda BalanDepartment of Public Health Dentistry, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India.
Sumathi EthirajDepartment of Biotechnology, Poonga Biotech Research Center, Plant Biotechnology Division, Choolaimedu, Chennai, Tamil Nadu, India.
Department of Public · INRagas Dental College & Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextDental caries, a ubiquitous multifactorial infectious disease, is primarily caused by microorganisms like Streptococcus mutans and Lactobacillus acidophilus. Use of antimicrobials is an important strategy to curb cariogenic microorganisms.

aimThe aim was to evaluate the in vitro antimicrobial activity of C. sinensis extract on S. mutans and L. acidophilus. STUDY SETTING AND

designExperimental design, in vitro study, lab setting. MATERIALS AND

methodsAqueous, acetone and ethanolic extracts of C. sinensis were subjected to antioxidant analysis. The ethanolic extract was used for assessment of antimicrobial properties. Ethanolic green tea extract at ten different concentrations and 0.2% chlorhexidine was used. Microbiological investigations were carried out to determine the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and zone of Inhibition of the test and control agents against S. mutans and L. acidophilus. STATISTICAL ANALYSIS: Kruskall-Wallis and Mann-Whitney U-test.

resultsMIC of green tea extract on S. mutans and L. acidophilus was found to be 0.2% and 0.3% respectively, MBC was found to be 0.8% and 0.9%, respectively. The mean zone of inhibition for 30 μl containing 300 μg of ethanolic extract of green tea and control against S. mutans were 18.33 mm and 14.67 mm, respectively. The mean zone of inhibition for 30 μl containing 300 μg of ethanolic extract of green tea and control against L. acidophilus were 12.67 mm and 7.33 mm, respectively.

conclusionGreen tea has antibacterial activity against predominant cariogenic bacteria namely S. mutans and L. acidophilus.

Indexed as

Camellia sinensisdental cariesgreen teaphytochemical analysis

Identifiers

PMID25538470
PMCPMC4268628
OpenAlexW2059564349

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.