Evidence map›Paper›PMID 25538335›Full record

ArticleIndian journal of pharmacology

Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats.

Rajesh A Maheshwari, R Balaraman, Ashim K Sen, A K Seth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  10. Coenzyme QAntioxidants (Basel, Switzerland) · 2020
    Review
  11. Article
  12. Cyclophilin A (CyPA) as a Novel Biomarker for Early Detection of Diabetic Nephropathy in an Animal Model.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020
    Article
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rajesh A MaheshwariDepartment of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.
R BalaramanDepartment of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.
Ashim K SenDepartment of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.
A K SethDepartment of Pharmacy, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study was aimed to investigate the therapeutic potential of coenzyme Q10 and its combination with metformin on streptozotocin (STZ)-nicotinamide-induced diabetic nephropathy (DN). MATERIALS AND

methodsType 2 diabetes in rats was induced with STZ-nicotinamide. The diabetic rats were treated with coenzyme Q10 (10 mg/kg, p.o.) alone or coenzyme Q10 + metformin. Various parameters of renal function tests such as serum creatinine, urea, uric acid, and markers of oxidative stress such as renal malondialdehyde (MDA) level, superoxide dismutase (SOD), and catalase (CAT) activities were measured. Tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) activity, transforming growth factor-β (TGF-β), and nitrite content were estimated in renal tissues. All treated animal were subjected to histopathological changes of kidney.

resultDiabetic rats showed a significant reduction in renal function, which was reflected with an increase in serum urea, serum creatinine, uric acid. In addition, STZ-nicotinamide caused renal tubular damage with a higher MDA level, depletion of SOD and CAT activity and glutathione (GSH) level. Moreover, TNF-α, MPO activity, TGF-β, and nitrite content were significantly increased in diabetic rats, while treatment with coenzyme Q10 or metformin or their combination ameliorate STZ-nicotinamide induced renal damage due to improvement in renal function, oxidative stress, suppression of TNF-α, MPO activity, TGF-β and nitrite content along with histopathological changes.

conclusionsThis finding suggests that the treatment with coenzyme Q10 or metformin showed significant renoprotective effect against STZ-nicotinamide-induced DN. However, concomitant administration of both showed a better renoprotective effect than coenzyme Q10 or metformin alone treatment.

Indexed as

AnimalsCreatinineDiabetes Mellitus, ExperimentalDiabetic NephropathiesDrug Therapy, CombinationFemaleHemoglobinsHypoglycemic AgentsKidneyMaleMetforminNiacinamideNitritesPeroxidaseProtective AgentsRats, Wistarcoenzyme Q10CreatinineHemoglobinsHypoglycemic AgentsMetforminNiacinamideNitritesPeroxidaseProtective AgentsStreptozocinTransforming Growth Factor betaTumor Necrosis Factor-alphaUbiquinoneUreaUric AcidCoenzyme Q10diabetic nephropathymetformintransforming growth factor-βtumor necrosis factor-α

Identifiers

PMID25538335
PMCPMC4264079
OpenAlexW2005802877

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.