SynthesisIndian journal of pharmacology
Colchicine in prevention of atrial fibrillation following cardiac surgery: systematic review and meta-analysis.
Synthesis in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Colchicine for the primary prevention of cardiovascular events.The Cochrane database of systematic reviews · 2025Pooled it
- Colchicine for prevention of cardiovascular events.The Cochrane database of systematic reviews · 2016Pooled it
- Exploring Anti-Inflammatory Treatment as Upstream Therapy in the Management of Atrial Fibrillation.Journal of clinical medicine · 2025Review
- Review
- The Effect of Colchicine on Atrial Fibrillation: A Systematic Review and Meta-Analysis.Cureus · 2023Review
- Colchicine in atrial fibrillation: are old trees in bloom?Frontiers in physiology · 2023Review
- Inflammation, atrial fibrillation, and the potential role for colchicine therapy.Heart rhythm O2 · 2021Article
- Inflammation May be the Future of Cardiovascular Risk Reduction: Does Colchicine have a Current Indication?American journal of cardiovascular drugs : drugs, devices, and other interventions · 2021Review
- Anti-inflammatory drugs in the prevention of post-operative atrial fibrillation: a literature review.Inflammopharmacology · 2020Review
- New-Onset Atrial Fibrillation in Adult Patients After Cardiac Surgery.Current anesthesiology reports · 2019Article
- Article
- Efficacy of ranolazine in preventing atrial fibrillation following cardiac surgery: Results from a meta-analysis.Journal of arrhythmia · 2017Review
- Effect of colchicine in prevention of pericardial effusion and atrial fibrillation: a meta-analysis.Internal and emergency medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesInflammation is one of the predictors of atrial fibrillation (AF) following surgical or interventional cardiac procedures. Recent evidence suggests that colchicine may represent a new strategy to prevent AF following cardiac procedures. This study aims to assess the antiinflammatory efficacy of colchicine in prevention of early AF event (EAFE). MATERIALS AND
methodsWe reviewed all available studies that assessed the effectiveness of colchicine therapy on the occurrence of AF in patients undergoing cardiac procedures. Meta-analysis was performed by random effect inverse variance-weighted method by entering AF events and the total population from each study.
resultsAfter thorough review of the databases, we found three studies comparing colchicine and placebo which had EAFE as the outcome. Of 584 patients, 286 patients were on colchicine and 298 on placebo. All the three studies were randomized. After pooled analysis, colchicine was associated with significant reduction in AF events compared to placebo (odds ratio = 0.44 [0.29, 0.66], P < 0.001). There was no statistical heterogeneity between included studies (χ(2) = 0.45, P = 0.80, I(2) = 0%).
conclusionColchicine may prove beneficial in the prevention of AF following cardiac surgery. Further research is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.