ArticleEuropean radiology2015
Dual energy computed tomography quantification of carotid plaques calcification: comparison between monochromatic and polychromatic energies with pathology correlation.
Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Automatic spectral imaging protocol and iterative reconstruction for radiation dose reduction in typical hepatic hemangioma computed tomography with reduced iodine load: a preliminary study.The British journal of radiology · 2018Trial
- Plaque-Adapted Virtual Monoenergetic Image Selection for Carotid Plaque Visualization Using Photon-Counting CT.Diagnostics (Basel, Switzerland) · 2026Article
- Comparison of Carotid Plaque Ultrasound and Computed Tomography in Patients and Ex Vivo Specimens-Agreement of Composition Analysis.Journal of clinical medicine · 2026Article
- Contrast medium dose optimization in the era of multi-energy CT.Japanese journal of radiology · 2025Review
- Extracranial carotid plaque calcification and its association with risk factors for cerebrovascular events: insights from the ANTIQUE study.Frontiers in neurology · 2025Article
- Improved Detection of Small and Low-Density Plaques in Virtual Noncontrast Imaging-based Calcium Scoring at Photon-Counting Detector CT.Radiology. Cardiothoracic imaging · 2024Article
- Atherosclerotic plaque features relevant to rupture-risk detected by clinical photon-counting CT ex vivo: a proof-of-concept study.European radiology experimental · 2024Article
- Comparison of Photon-counting Detector and Energy-integrating Detector CT for Visual Estimation of Coronary Percent Luminal Stenosis.Radiology · 2023Article
- Unstable plaques hide in heavily calcified coronary arteries.Quantitative imaging in medicine and surgery · 2022Article
- Circumferential degree of carotid calcification is associated with new ischemic brain lesions after carotid artery stenting.Quantitative imaging in medicine and surgery · 2021Article
- Effect of energy difference in the evaluation of calcification size and luminal diameter in calcified coronary artery plaque using spectral CT.Japanese journal of radiology · 2020Article
- CT imaging features of carotid artery plaque vulnerability.Annals of translational medicine · 2020Review
- Plaque imaging volume analysis: technique and application.Cardiovascular diagnosis and therapy · 2020Review
- Variation of degree of stenosis quantification using different energy level with dual energy CT scanner.Neuroradiology · 2019Article
- Diagnostic performance of calcification-suppressed coronary CT angiography using rapid kilovolt-switching dual-energy CT.European radiology · 2017Article
- Advanced MRI for carotid plaque imaging.The international journal of cardiovascular imaging · 2016Review
- Assessment of carotid plaque composition using fast-kV switching dual-energy CT with gemstone detector: comparison with extracorporeal and virtual histology-intravascular ultrasound.Neuroradiology · 2015Article
- Image Quality and Dose Reduction by Dual Source Computed Tomography Coronary Angiography: Protocol Comparison.Dose-response : a publication of International Hormesis SocietyArticle
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10 authors.
Funding
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Abstract
purposeWe compared carotid plaque calcification detection sensitivity and apparent cross-sectional area on CT as a function of CT beam energy using conventional CT techniques and virtual mono-energetic CT images generated from dual-energy acquisitions. METHODS & MATERIALS: Five ex-vivo carotid endarterectomy (CEA) specimens were imaged with dual-energy computed tomography. Virtual monochromatic spectrum (VMS) CT images were reconstructed at energies between 40-140 keV. The same specimens were imaged using conventional polyenergetic spectrum (PS) CT with peak beam energies 80, 100, 120, and 140 kVp. The histological calcium areas on each corresponding CEA specimen were traced manually on digitized images of Toluidine-Blue/Basic-Fuchsin stained plastic sections.
results40 keV VMS CT images provided high detection sensitivity (97 %) similar to conventional PS CT images (~96 %). The calcification size measured on CT decreased systematically with increasing CT beam energy; the rate of change was larger for the VMS images than for PS images.
conclusionFrom a single dual-energy CT, multiple VMS-CT images can be generated, yielding equivalent detection sensitivity and size correlations as conventional PS-CT in CEA calcification imaging. VMS-CT at 80-100 keV provided the most accurate estimates of calcification size, as compared to histology, but detection sensitivity was reduced for smaller calcifications on these images. KEY POINTS: • Calcifications depicted at 80-100 keV were most similar to the histology standard. • Conventional polychromatic images demonstrated excellent correlation with plaque size at pathology. • Conventional polychromatic images systematically overestimate plaque size. • Plaque calcifications can be missed on high energy monochromatic images.
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