ArticleJournal of the American Geriatrics Society2015
Statin use and decline in gait speed in community-dwelling older adults.
Article in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of statins on falls and physical activity in people aged 65 and older: A systematic review.European journal of clinical pharmacology · 2024Pooled it
- Amelioration of gait and balance disorders by rosuvastatin is associated with changes in cerebrovascular reactivity in older patients with hypertensive treatment.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Trial
- The association between statins and gait speed reserve in older adults: effects of concomitant medication.GeroScience · 2026Observational
- Polypharmacy Results in Functional Impairment in Mice: Novel Insights Into Age and Sex Interactions.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Association between Statin Use and Physical Function among Older Chinese Inpatients with Type 2 Diabetes.The journal of nutrition, health & aging · 2020Article
- Statins for Primary Prevention of Cardiovascular Events and Mortality in Older Men.Journal of the American Geriatrics Society · 2017Article
- Deprescribing in Older Nursing Home Patients: Focus on Innovative Composite Measures for Dosage Deintensification.Innovation in aging · 2017Review
- Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort.Scientific reports · 2017Article
- Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
objectivesTo examine the association between statin use and objectively assessed decline in gait speed in community-dwelling older adults.
designLongitudinal cohort study.
settingHealth, Aging and Body Composition (Health ABC) Study.
participantsTwo thousand five participants aged 70-79 at baseline with medication and gait speed data at 1998-99, 1999-2000, 2001-02, and 2002-03. MEASUREMENTS: The independent variables were any statin use and their standardized daily doses (low, moderate, high) and lipophilicity. The primary outcome measure was decline in gait speed of 0.1 m/s or more in the following year of statin use. Multivariable generalized estimating equations were used, adjusting for demographic characteristics, health-related behaviors, health status, and access to health care.
resultsStatin use increased from 16.2% in 1998-99 to 25.6% in 2002-03. The overall proportions of those with decline in gait speed of 0.1 m/s or more increased from 22.2% in 1998 to 23.9% in 2003. Statin use was not associated with decline in gait speed of 0.1 m/s or more (adjusted odds ratio (AOR) = 0.90, 95% confidence interval (CI) = 0.77-1.06). Similar nonsignificant trends were also seen with the use of hydrophilic or lipophilic statins. Users of low-dose statins were found to have a 22% lower risk of decline in gait speed than nonusers (AOR = 0.78, 95% CI = 0.61-0.99), which was mainly driven by the results from 1999-2000 follow-up.
conclusionThese results suggest that statin use did not increase decline in gait speed in community-dwelling older adults.
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