ArticleBiology of reproduction2015
Placental growth factor influences maternal cardiovascular adaptation to pregnancy in mice.
Article in Biology of reproduction, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Metabolic abnormalities and obesity's impact on the risk for developing preeclampsia.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Pooled it
- Late vs. Early Preeclampsia.International journal of molecular sciences · 2025Review
- Anesthetic Management of the Pregnant Patient: Part 1.Anesthesia progress · 2021Review
- Regulation of Uterine Spiral Artery Remodeling: a Review.Reproductive sciences (Thousand Oaks, Calif.) · 2020Review
- Lasting Effects of Intrauterine Exposure to Preeclampsia on Offspring and the Underlying Mechanism.AJP reports · 2019Review
- Adult PgfScientific reports · 2019Article
- Placental Growth Factor as an Indicator of Maternal Cardiovascular Risk After Pregnancy.Circulation · 2019Article
- Maternal cardiac messenger RNA expression of extracellular matrix proteins in mice during pregnancy and the postpartum period.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice.The Journal of clinical investigation · 2018Article
- Effects of placental growth factor deficiency on behavior, neuroanatomy, and cerebrovasculature of mice.Physiological genomics · 2018Article
- Expression of placental regulatory genes is associated with fetal growth.Journal of perinatal medicine · 2017Article
- Impact of Immune Deficiency on Remodeling of Maternal Resistance Vasculature 4 Weeks Postpartum in Mice.Reproductive sciences (Thousand Oaks, Calif.) · 2017Article
- Impacts of Preeclampsia on the Brain of the Offspring.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2016Review
- Placental growth factor deficiency is associated with impaired cerebral vascular development in mice.Molecular human reproduction · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
In healthy human pregnancies, placental growth factor (PGF) concentrations rise in maternal plasma during early gestation, peak over Weeks 26-30, then decline. Because PGF in nongravid subjects participates in protection against and recovery from cardiac pathologies, we asked if PGF contributes to pregnancy-induced maternal cardiovascular adaptations. Cardiovascular function and structure were evaluated in virgin, pregnant, and postpartum C56BL/6-Pgf(-) (/) (-) (Pgf(-) (/) (-)) and C57BL/6-Pgf(+/+) (B6) mice using plethysmography, ultrasound, quantitative PCR, and cardiac and renal histology. Pgf(-/-) females had higher systolic blood pressure in early and late pregnancy but an extended, abnormal midpregnancy interval of depressed systolic pressure. Pgf(-/-) cardiac output was lower than gestation day (gd)-matched B6 after midpregnancy. While Pgf(-) (/) (-) left ventricular mass was greater than B6, only B6 showed the expected gestational gain in left ventricular mass. Expression of vasoactive genes in the left ventricle differed at gd8 with elevated Nos expression in Pgf(-) (/) (-) but not at gd14. By gd16, Pgf(-) (/) (-) kidneys were hypertrophic and had glomerular pathology. This study documents for the first time that PGF is associated with the systemic maternal cardiovascular adaptations to pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.