ArticleBiology of reproduction2015
Effect of vaginal or systemic estrogen on dynamics of collagen assembly in the rat vaginal wall.
Article in Biology of reproduction, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 74 citations in OpenAlex.
- Multidimensional regulation of estrogen signaling in pelvic floor connective tissue homeostasis and remodeling.Frontiers in immunology · 2026Review
- Role of the integrin‑β1/TGF‑β1 signaling pathway in the pathogenesis of pelvic organ prolapse: A study on vaginal wall tissue alterations and molecular dysfunction.Molecular medicine reports · 2025Article
- Evisceration of Abdominal Contents Through a Posterior Vaginal Defect: A Case Report.Case reports in obstetrics and gynecology · 2025Article
- Practical Guidance on the Use of Vaginal Laser Therapy: Focus on Genitourinary Syndrome and Other Symptoms.International journal of women's health · 2024Review
- Cellular and extracellular vaginal changes following murine ovarian removal.Physiological reports · 2023Article
- Collagen and elastic fiber remodeling in the pregnant mouse myometrium†.Biology of reproduction · 2022Article
- A Novel Technique Combining Human Acellular Dermal Matrix (HADM) and Enriched Platelet Therapy (EPT) for the Treatment of Vaginal Laxity: A Single-Arm, Observational Study.Aesthetic plastic surgery · 2022Observational
- Protease activities of vaginal Porphyromonas species disrupt coagulation and extracellular matrix in the cervicovaginal niche.NPJ biofilms and microbiomes · 2022Article
- Animal Models and Alternatives in Vaginal Research: a Comparative Review.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Vaginal Aging-What We Know and What We Do Not Know.International journal of environmental research and public health · 2021Review
- An Avant-Garde Model of Injury-Induced Regenerative Vaginal Wound Healing.Advances in wound care · 2021Article
- The absence of oestrogen receptor beta disturbs collagen I type deposition during Achilles tendon healing by regulating the IRF5-CCL3 axis.Journal of cellular and molecular medicine · 2020Article
- Collagen at the maternal-fetal interface in human pregnancy.International journal of biological sciences · 2020Review
- Emerging technologies in pediatric gynecology: new paradigms in women's health care.Current opinion in obstetrics & gynecology · 2019Review
- Effect of Protease Inhibitors in Healing of the Vaginal Wall.Scientific reports · 2019Article
- Tissue Composition and Biomechanical Property Changes in the Vaginal Wall of Ovariectomized Young Rats.BioMed research international · 2019Article
- The mysteries of menopause and urogynecologic health: clinical and scientific gaps.Menopause (New York, N.Y.) · 2019Review
- Dysregulation of fibulin-5 and matrix metalloproteases in epithelial ovarian cancer.Oncotarget · 2018Article
- Biaxial Mechanical Assessment of the Murine Vaginal Wall Using Extension-Inflation Testing.Journal of biomechanical engineering · 2017Article
- Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall.Menopause (New York, N.Y.) · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The objective of this study was to compare the effects of systemic and local estrogen treatment on collagen assembly and biomechanical properties of the vaginal wall. Ovariectomized nulliparous rats were treated with estradiol or conjugated equine estrogens (CEEs) either systemically, vaginal CEE, or vaginal placebo cream for 4 wk. Low-dose local CEE treatment resulted in increased vaginal epithelial thickness and significant vaginal growth without uterine hyperplasia. Furthermore, vaginal wall distensibility increased without compromise of maximal force at failure. Systemic estradiol resulted in modest increases in collagen type I with no change in collagen type III mRNA. Low-dose vaginal treatment, however, resulted in dramatic increases in both collagen subtypes whereas moderate and high dose local therapies were less effective. Consistent with the mRNA results, low-dose vaginal estrogen resulted in increased total and cross-linked collagen content. The inverse relationship between vaginal dose and collagen expression may be explained in part by progressive downregulation of estrogen receptor-alpha mRNA with increasing estrogen dose. We conclude that, in this menopausal rat model, local estrogen treatment increased total and cross-linked collagen content and markedly stimulated collagen mRNA expression in an inverse dose-effect relationship. High-dose vaginal estrogen resulted in downregulation of estrogen receptor-alpha and loss of estrogen-induced increases in vaginal collagen. These results may have important clinical implications regarding the use of local vaginal estrogen therapy and its role as an adjunctive treatment in women with loss of vaginal support.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.