ArticlePsychopharmacology2015
Acute administration of lithium, but not valproate, modulates cognitive judgment bias in rats.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Stress produces negative judgement bias in cuttlefish.Biology letters · 2024Article
- Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats.Psychopharmacology · 2024Article
- Application of Cognitive Bias Testing in Neuropsychiatric Disorders: A Mini-Review Based on Animal Studies.Frontiers in behavioral neuroscience · 2022Review
- Differential Effects of Serotonin Transporter Genotype on Anxiety-Like Behavior and Cognitive Judgment Bias in Mice.Frontiers in behavioral neuroscience · 2019Article
- Assessing animal affect: an automated and self-initiated judgement bias task based on natural investigative behaviour.Scientific reports · 2018Article
- Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice.Psychopharmacology · 2018Article
- Translational Assessments of Reward and Anhedonia: A Tribute to Athina Markou.Biological psychiatry · 2018Review
- Lesions of the Orbitofrontal but Not Medial Prefrontal Cortex Affect Cognitive Judgment Bias in Rats.Frontiers in behavioral neuroscience · 2017Article
- Molecular Signatures of Psychosocial Stress and Cognition Are Modulated by Chronic Lithium Treatment.Schizophrenia bulletin · 2016Article
- Making Decisions under Ambiguity: Judgment Bias Tasks for Assessing Emotional State in Animals.Frontiers in behavioral neuroscience · 2016Review
- Effects of optimism on motivation in rats.Frontiers in behavioral neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE AND
objectivesBoth valproic acid (VPA) and lithium (LI) are well-established treatments for therapy of intense and sustained mood shifts, which are characteristics of affective disorders, such as bipolar disorder (BP). As mood and cognitive judgment bias have been found to be strongly interrelated, the present study investigated, in an animal model, whether acute treatment with VPA or LI could affect cognitive judgment bias.
methodsTo accomplish this goal, two groups of rats received single injections of either VPA or LI after initial behavioral training and were subsequently tested with the ambiguous-cue interpretation (ACI) test. Both drugs were administered in three doses using the fully randomized Latin square design.
resultsVPA (100, 200, and 400 mg/kg) had no significant effect on the interpretation of the ambiguous cue. LI at the lowest dose (10 mg/kg) had no effect; at an intermediate dose (50 mg/kg), it significantly biased animals towards positive interpretation of the ambiguous cue, and at the highest dose (100 mg/kg), it impaired the ability of animals to complete the test.
conclusionTo our knowledge, this is the first study demonstrating lithium's effects on increased optimistic judgment bias. Future studies may focus on the ability of putative pharmacotherapies to modify the cognitive judgment bias dimension of patients at risk for bipolar disorder or depression.
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