Evidence map›Paper›PMID 25537147›Full record

ArticleClinical and experimental medicine2016

Polymorphisms in DNA repair genes and breast cancer risk in Russian population: a case-control study.

Alexandra S Shadrina, Natalia A Ermolenko, Uljana A Boyarskikh, Tatiana V Sinkina, Alexandr F Lazarev, Valentina D Petrova, Maxim L Filipenko

Abstract read
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In one paragraph

Article in Clinical and experimental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Genetic variants of thePrzeglad menopauzalny = Menopause review · 2024
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  10. Genetic Variations of DNA Repair Genes in Breast Cancer.Pathology oncology research : POR · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alexandra S ShadrinaInstitute of Chemical Biology and Fundamental Medicine, Lavrentjeva, 8, 630090, Novosibirsk, Russia. weiner.alexserg@gmail.com.
Natalia A ErmolenkoInstitute of Chemical Biology and Fundamental Medicine, Lavrentjeva, 8, 630090, Novosibirsk, Russia.
Uljana A BoyarskikhInstitute of Chemical Biology and Fundamental Medicine, Lavrentjeva, 8, 630090, Novosibirsk, Russia.
Tatiana V SinkinaAltai Branch of the Russian Blokhin Cancer Research Centre, Nikitina Street, 77, 656049, Barnaul, Russia.
Alexandr F LazarevAltai Branch of the Russian Blokhin Cancer Research Centre, Nikitina Street, 77, 656049, Barnaul, Russia.
Valentina D PetrovaAltai Branch of the Russian Blokhin Cancer Research Centre, Nikitina Street, 77, 656049, Barnaul, Russia.
Maxim L FilipenkoInstitute of Chemical Biology and Fundamental Medicine, Lavrentjeva, 8, 630090, Novosibirsk, Russia.
Russian Cancer Research Center NN Blokhin · RUNovosibirsk State University · RUInstitute of Chemical Biology and Fundamental Medicine · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic variation in DNA repair genes can alter an individual's capacity to repair damaged DNA and influence the risk of cancer. We tested seven polymorphisms in DNA repair genes XRCC1, ERCC2, XRCC3, XRCC2, EXOI and TP53 for a possible association with breast cancer risk in a sample of 672 case and 672 control Russian women. An association was observed for allele A of the polymorphism XRCC1 (R399Q) rs25487 (co-dominant model AA vs. GG: OR 1.76, P = 0.003; additive model OR 1.28, P = 0.005; dominant model: OR 1.29, P = 0.03; recessive model OR 1.63, P = 0.008). Allele T of the polymorphism ERCC2 (D312N) rs1799793 was also associated with breast cancer risk (co-dominant model TT vs. CC: OR 1.43, P = 0.04; additive model OR 1.21, P = 0.02; dominant model: OR 1.30, P = 0.02), but the association became insignificant after applying Bonferroni correction. No association with breast cancer was found for the remaining SNPs. In summary, our study provides evidence that polymorphisms in DNA repair genes may play a role in susceptibility to breast cancer in the population of ethnical Russians.

Indexed as

Polymorphism, Single NucleotideAdultAgedAged, 80 and overBreast NeoplasmsCase-Control StudiesDNA-Binding ProteinsDNA RepairFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansMiddle AgedRussiaWhite PeopleXeroderma Pigmentosum Group D ProteinDNA-Binding ProteinsERCC2 protein, humanXeroderma Pigmentosum Group D ProteinX-ray Repair Cross Complementing Protein 1XRCC1 protein, humanBreast cancerDNA repairRussian populationSNP

Identifiers

PMID25537147
OpenAlexW2075110060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.