ArticleCell stress & chaperones2015
The global effect of heat on gene expression in cultured bovine mammary epithelial cells.
Article in Cell stress & chaperones, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Impact of Dietary Supplementation withAnimals : an open access journal from MDPI · 2025Article
- Decoding the beef cattle genome through whole-genome sequencing reveals the genetic basis of carcass and meat quality traits.Scientific reports · 2025Article
- MiR- 223 alleviates the heat-stress-induced inhibition of cell proliferation by targeting PRDM1.BMC genomics · 2025Article
- UFBP1 Ameliorates Heat Stress-Induced Apoptosis via Mitochondria-Mediated Pathway in Bovine Mammary Epithelial Cells.Animals : an open access journal from MDPI · 2025Article
- Proteomic identification of potential biomarkers for heat tolerance in Caracu beef cattle using high and low thermotolerant groups.BMC genomics · 2024Article
- Novel Perspective on Molecular and Cellular Adaptations of the Mammary Gland-Regulating Milk Constituents and Immunity of Heat-Stressed Dairy Cows.Journal of agricultural and food chemistry · 2024Article
- miR-196a Promotes Proliferation of Mammary Epithelial Cells by TargetingAnimals : an open access journal from MDPI · 2023Article
- Plant Extracts to Alleviating Heat Stress in Dairy Cows.Animals : an open access journal from MDPI · 2023Review
- Impact of heat stress on dairy cattle and selection strategies for thermotolerance: a review.Frontiers in veterinary science · 2023Review
- The alteration of N6-methyladenosine (m6A) modification at the transcriptome-wide level in response of heat stress in bovine mammary epithelial cells.BMC genomics · 2022Article
- Depletion of serum-derived exosomes aggravates heat stress-induced damage of bovine mammary epithelial cells.Molecular biology reports · 2022Article
- Adverse Effects of High Temperature On Mammary Alveolar Development In Vitro.Journal of mammary gland biology and neoplasia · 2022Article
- Carry-over effects of dry period heat stress on the mammary gland proteome and phosphoproteome in the subsequent lactation of dairy cows.Scientific reports · 2022Article
- CircEZH2 Regulates Milk Fat Metabolism through miR-378b Sponge Activity.Animals : an open access journal from MDPI · 2022Article
- In vitro effects of 5-Hydroxy-L-tryptophan supplementation on primary bovine mammary epithelial cell gene expression under thermoneutral or heat shock conditions.Scientific reports · 2022Article
- Effect of hyperthermia on cell viability, amino acid transfer, and milk protein synthesis in bovine mammary epithelial cells.Journal of animal science and technology · 2022Article
- Effect of Heat Stress on Bovine Mammary Cellular Metabolites and Gene Transcription Related to Amino Acid Metabolism, Amino Acid Transportation and Mammalian Target of Rapamycin (mTOR) Signaling.Animals : an open access journal from MDPI · 2021Article
- Enhanced supply of methionine regulates protein synthesis in bovine mammary epithelial cells under hyperthermia condition.Journal of animal science and technology · 2021Article
- Heat stress and immune response phenotype affect DNA methylation in blood mononuclear cells from Holstein dairy cows.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress (HS) in hot climates is a major cause that strongly negatively affects milk yield in dairy cattle, leading to immeasurable economic loss. The heat stress response of bovine mammary epithelial cells (BMECs) is one component of the acute systemic response to HS. Gene networks of BMECs respond to environmental heat loads with both intra- and extracellular signals that coordinate cellular and whole-animal metabolism. Our experimental objective was to characterize the direct effects of heat stress on the cultured bovine mammary epithelial cells by microarray analyses. The data identified 2716 differentially expressed genes in 43,000 transcripts which were changed significantly between heat-stressed and normal bovine mammary epithelial cells (fold change ≥2, P ≤ 0.001). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that these differentially expressed genes are involved in different pathways that regulate cytoskeleton, cell cycle, and stress response processes. Our study provides an overview of gene expression profile and the interaction between gene expression and heat stress, which will lead to further understanding of the potential effects of heat stress on bovine mammary glands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.