ArticleEnvironmental health perspectives2015
Association between lung function in adults and plasma DDT and DDE levels: results from the Canadian Health Measures Survey.
Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 24 citations in OpenAlex.
- Identification of Environmental Exposures Associated with Risk of Sarcoidosis in African Americans.Annals of the American Thoracic Society · 2023Article
- The outcome and the influencing factors of the age of onset in post-mortem of chronic bronchitis patients: a retrospective study.International journal of chronic obstructive pulmonary disease · 2018Article
- Body Burden of Dichlorodiphenyl Dichloroethene (DDE) and Childhood Pulmonary Function.International journal of environmental research and public health · 2017Article
- Genetic and methylation variation in the CYP2B6 gene is related to circulating p,p'-dde levels in a population-based sample.Environment international · 2017Article
- Pulmonary health effects of agriculture.Current opinion in pulmonary medicine · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough DDT [1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane] has been banned in many countries since the 1970s, it may still pose a risk to human respiratory health. In agriculture, DDT exposures have been associated with asthma and chronic bronchitis. However, little is known about the effect of DDT on lung function.
methodsWe used data on 1,696 participants 20-79 years of age from the Canadian Health Measures Survey (CHMS) and conducted multiple regression analysis to estimate associations between plasma p,p´-DDT/DDE and lung function.
resultsAlmost all participants (> 99.0%) had detectable concentrations of plasma p,p´-DDE, but only 10.0% had detectable p,p´-DDT. Participants with detectable p,p´-DDT had significantly lower mean FVC (difference = 311 mL; 95% CI: -492, -130; p = 0.003) and FEV1 (difference = 232 mL; 95% CI: -408, -55; p = 0.015) than those without. A 100-ng/g lipid increase in plasma p,p´-DDE was associated with an 18.8-mL decrease in mean FVC (95% CI: -29, -9) and an 11.8-mL decrease in mean FEV1 (95% CI: -21, -3). Neither exposure was associated with FEV1/FVC ratio or FEF25%-75%.
conclusionsDDT exposures, which may have occurred decades ago, were still detectable among Canadians. Plasma DDT and DDE were negatively associated with lung function parameters. Additional research on the potential effects of DDT use on lung function is warranted.
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