Trial reportAnnals of surgery2015
Active Negative Pressure Peritoneal Therapy After Abbreviated Laparotomy: The Intraperitoneal Vacuum Randomized Controlled Trial.
Trial report in Annals of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 52 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Peritoneal Vacuum Therapy to Reduce the Systemic Inflammatory Insult From Intraperitoneal Sepsis/Injury/Hypertension: A Randomized Comparison of Baseline Wall Suction Versus the KCI AbThera™ Abdominal Dressing
Closed Versus Open Abdomen in the Surgical Treatment of Severe Secondary Peritonitis: a Randomized Controlled Clinical Trial
Use of the ABTHERA ADVANCE™ Open Abdomen Dressing in Patients With Necrotizing Pancreatitis
Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Closed incision negative pressure wound therapy after emergency laparotomy: a systematic review and Meta-analysis of randomized controlled trials.World journal of emergency surgery : WJES · 2026Pooled it
- Negative pressure wound therapy for managing the open abdomen in non-trauma patients.The Cochrane database of systematic reviews · 2022Pooled it
- Chinese Trauma Surgeon Association for management guidelines of vacuum sealing drainage application in abdominal surgeries-Update and systematic review.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2019Pooled it
- EHS clinical guidelines on the management of the abdominal wall in the context of the open or burst abdomen.Hernia : the journal of hernias and abdominal wall surgery · 2018Guideline
- The unrestricted global effort to complete the COOL trial.World journal of emergency surgery : WJES · 2023Trial
- Bioelectrical impedance analysis-guided fluid management promotes primary fascial closure after open abdomen: a randomized controlled trial.Military Medical Research · 2021Trial
- Ethical considerations in conducting surgical research in severe complicated intra-abdominal sepsis.World journal of emergency surgery : WJES · 2019Trial
- High Mobility Group Box-1 Protein and Outcomes in Critically Ill Surgical Patients Requiring Open Abdominal Management.Mediators of inflammation · 2017Trial
- Article
- Vacuum-Assisted Wound Therapy in Bothrops Snakebite Injuries: A Case Series from the Brazilian Amazon.Journal of clinical medicine · 2025Article
- Article
- Review
- Safety and feasibility of open abdomen with negative pressure therapy in major liver trauma: a retrospective bicenter study.Langenbeck's archives of surgery · 2025Article
- Vacuum-Assisted Closure Significantly Reduces Surgical Postoperative Complications Compared With Primary Abdominal Closure in Patients With Secondary Peritonitis: A Comparative Retrospective Study.World journal of surgery · 2025Article
- Narrative Review of Open Abdomen Management and Comparison of Different Temporary Abdominal Closure Techniques.Journal of abdominal wall surgery : JAWS · 2025Review
- Organ Donation after Open Abdominal Management with Negative-Pressure Dressing: A Case Report.Surgical case reports · 2025Article
- Intra-abdominal hypertension/abdominal compartment syndrome of pediatric patients in critical care settings.Open medicine (Warsaw, Poland) · 2025Review
- Pharmacokinetics of Piperacillin-Tazobactam in Critically Ill Patients with Open Abdomen and Vacuum-Assisted Wound Closure: Dosing Considerations Using Monte Carlo Simulation.Pharmaceutics · 2024Article
- Open or closed abdomen post laparotomy to control severe abdominal sepsis: a survival analysis.Revista do Colegio Brasileiro de Cirurgioes · 2024Article
- The open abdomen in trauma, acute care, and vascular and endovascular surgery: comprehensive, expert, narrative review.BJS open · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether active negative pressure peritoneal therapy with the ABThera temporary abdominal closure device reduces systemic inflammation after abbreviated laparotomy.
backgroundExcessive systemic inflammation after abdominal injury or intra-abdominal sepsis is associated with poor outcomes.
methodsWe conducted a single-center, randomized controlled trial. Forty-five adults with abdominal injury (46.7%) or intra-abdominal sepsis (52.3%) were randomly allocated to the ABThera (n = 23) or Barker's vacuum pack (n = 22). On study days 1, 2, 3, 7, and 28, blood and peritoneal fluid were collected. The primary endpoint was the difference in the plasma concentration of interleukin-6 (IL-6) 24 and 48 hours after temporary abdominal closure application.
resultsThere was a significantly lower peritoneal fluid drainage from the ABThera at 48 hours after randomization. Despite this, there was no difference in plasma concentration of IL-6 at baseline versus 24 (P = 0.52) or 48 hours (P = 0.82) between the groups. There was also no significant intergroup difference in the plasma concentrations of IL-1β, -8, -10, or -12 p70 or tumor necrosis factor α between these time points. The cumulative incidence of primary fascial closure at 90 days was similar between groups (hazard ratio, 1.6; 95% confidence interval, 0.82-3.0; P = 0.17). However, 90-day mortality was improved in the ABThera group (hazard ratio, 0.32; 95% confidence interval, 0.11-0.93; P = 0.04).
conclusionsThis trial observed a survival difference between patients randomized to the ABThera versus Barker's vacuum pack that did not seem to be mediated by an improvement in peritoneal fluid drainage, fascial closure rates, or markers of systemic inflammation.
trial registrationClinicalTrials.gov identifier NCT01355094.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.