ArticlePloS one2014
Amyloid β-mediated Zn2+ influx into dentate granule cells transiently induces a short-term cognitive deficit.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Metallothionein synthesis increased by Ninjin-yoei-to, a Kampo medicine protects neuronal death and memory loss after exposure to amyloid βJournal of pharmaceutical health care and sciences · 2022Article
- Isoproterenol, an adrenergic β receptor agonist, induces metallothionein synthesis followed by canceling amyloid βBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- Preventive effect of Ninjin-yoei-to, a Kampo medicine, on amyloid βExperimental animals · 2021Article
- Extracellular ZnBiological trace element research · 2021Review
- Alzheimer risk factors age and female sex induce cortical Aβ aggregation by raising extracellular zinc.Molecular psychiatry · 2020Article
- Preferential Neurodegeneration in the Dentate Gyrus by Amyloid βMolecular neurobiology · 2020Article
- The Interplay Between Beta-Amyloid 1-42 (AβFrontiers in molecular neuroscience · 2020Article
- Amyloid βMolecular neurobiology · 2019Article
- Blockade of Rapid Influx of Extracellular ZnMolecular neurobiology · 2019Article
- In vivo synaptic activity-independent co-uptakes of amyloid βScientific reports · 2019Article
- Novel Defense by Metallothionein Induction Against Cognitive Decline: From Amyloid βMolecular neurobiology · 2018Article
- Weakened Intracellular ZnMolecular neurobiology · 2018Article
- Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer's disease.Scientific reports · 2018Article
- Extracellular ZnThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined an idea that short-term cognition is transiently affected by a state of confusion in Zn2+ transport system due to a local increase in amyloid-β (Aβ) concentration. A single injection of Aβ (25 pmol) into the dentate gyrus affected dentate gyrus long-term potentiation (LTP) 1 h after the injection, but not 4 h after the injection. Simultaneously, 1-h memory of object recognition was affected when the training was performed 1 h after the injection, but not 4 h after the injection. Aβ-mediated impairments of LTP and memory were rescued in the presence of zinc chelators, suggesting that Zn2+ is involved in Aβ action. When Aβ was injected into the dentate gyrus, intracellular Zn2+ levels were increased only in the injected area in the dentate gyrus, suggesting that Aβ induces the influx of Zn2+ into cells in the injected area. When Aβ was added to hippocampal slices, Aβ did not increase intracellular Zn2+ levels in the dentate granule cell layer in ACSF without Zn2+, but in ACSF containing Zn2+. The increase in intracellular Zn2+ levels was inhibited in the presence of CaEDTA, an extracellular zinc chelator, but not in the presence of CNQX, an AMPA receptor antagonist. The present study indicates that Aβ-mediated Zn2+ influx into dentate granule cells, which may occur without AMPA receptor activation, transiently induces a short-term cognitive deficit. Extracellular Zn2+ may play a key role for transiently Aβ-induced cognition deficits.
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