ArticlePloS one2014
Gestational age and neonatal brain microstructure in term born infants: a birth cohort study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Depressive symptoms and gestational length among pregnant adolescents: Cluster randomized control trial of CenteringPregnancy® plus group prenatal care.Journal of consulting and clinical psychology · 2017Trial
- Dynamics of infant white matter maturation from birth to 6 months.Communications biology · 2026Article
- Lower gestational age is associated with lower cortical volume and cognitive and educational performance in adolescence.BMC medicine · 2022Article
- Longitudinal assessment of early-life white matter development with quantitative relaxometry in nonhuman primates.NeuroImage · 2022Article
- Development of functional organization within the sensorimotor network across the perinatal period.Human brain mapping · 2022Article
- Effects of gestational age at birth on perinatal structural brain development in healthy term-born babies.Human brain mapping · 2022Article
- Infant and Child MRI: A Review of Scanning Procedures.Frontiers in neuroscience · 2021Review
- The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Associations of gestational age and birth anthropometric indicators with brain white matter maturation in full-term neonates.Human brain mapping · 2019Article
- Proper timing for the evaluation of neonatal brain white matter development: a diffusion tensor imaging study.European radiology · 2019Article
- Computational neuroanatomy of baby brains: A review.NeuroImage · 2019Review
- Infant Brain Structural MRI Analysis in the Context of Thoracic Non-cardiac Surgery and Critical Care.Frontiers in pediatrics · 2019Article
- Association of Prenatal Maternal Depression and Anxiety Symptoms With Infant White Matter Microstructure.JAMA pediatrics · 2018Article
- Gestational Age at Birth and Brain White Matter Development in Term-Born Infants and Children.AJNR. American journal of neuroradiology · 2017Article
- Gestational Age and Cardiorespiratory Fitness in Individuals Born At Term: A Life Course Study.Journal of the American Heart Association · 2017Article
- Complementary cortical gray and white matter developmental patterns in healthy, preterm neonates.Human brain mapping · 2017Article
- Mapping White Matter Microstructure in the One Month Human Brain.Scientific reports · 2017Article
- Maternal prenatal iron status and tissue organization in the neonatal brain.Pediatric research · 2016Article
- Initial Application of Diffusional Kurtosis Imaging in Evaluating Brain Development of Healthy Preterm Infants.PloS one · 2016Article
- Diffusion tensor imaging for understanding brain development in early life.Annual review of psychology · 2015Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveUnderstanding healthy brain development in utero is crucial in order to detect abnormal developmental trajectories due to developmental disorders. However, in most studies neuroimaging was done after a significant postnatal period, and in those studies that performed neuroimaging on fetuses, the quality of data has been affected due to complications of scanning during pregnancy. To understand healthy brain development between 37-41 weeks of gestational age, our study assessed the in utero growth of the brain in healthy term born babies with DTI scanning soon after birth.
methodsA cohort of 93 infants recruited from maternity hospitals in Singapore underwent diffusion tensor imaging between 5 to 17 days after birth. We did a cross-sectional examination of white matter microstructure of the brain among healthy term infants as a function of gestational age via voxel-based analysis on fractional anisotropy.
resultsGreater gestational age at birth in term infants was associated with larger fractional anisotropy values in early developing brain regions, when corrected for age at scan. Specifically, it was associated with a cluster located at the corpus callosum (corrected p<0.001), as well as another cluster spanning areas of the anterior corona radiata, anterior limb of internal capsule, and external capsule (corrected p<0.001).
conclusionsOur findings show variation in brain maturation associated with gestational age amongst 'term' infants, with increased brain maturation when born with a relatively higher gestational age in comparison to those infants born with a relatively younger gestational age. Future studies should explore if these differences in brain maturation between 37 and 41 weeks of gestational age will persist over time due to development outside the womb.
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