ArticleThe ISME journal2015
Comparative metagenomic and metatranscriptomic analyses of microbial communities in acid mine drainage.
Article in The ISME journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed.
- Integrated framework assessment of water reuse feasibility in mining.Environmental geochemistry and health · 2026Article
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- Photosynthetic Diel Cycling Influences Inverse Zinc and Copper Solubility Dynamics within a Constructed Wetland.Environmental science & technology · 2026Article
- Metagenome Insights into Armenian Acid Mine Drainage: A Novel Thermoacidophilic Iron-Oxidizing Bacterium with Perspectives for Copper Bioleaching.Microorganisms · 2026Article
- Unique characteristics of acid-tolerant comammox bacteria revealed by multi-omics analyses.ISME communications · 2026Article
- Sulfate-reducing bacteria in acid mine drainage: ecological constraints, microbial networks, and functional persistence.Frontiers in microbiology · 2026Review
- Metatranscriptomic insights into the effect ofFrontiers in microbiology · 2026Article
- Polysaccharide-degrading archaea dominate acidic hot springs: genomic and cultivation insights into a novelmSystems · 2025Article
- Tracing non-fungal eukaryotic diversity via shotgun metagenomes in the complex mudflat intertidal zones.mSystems · 2025Article
- Dominant Dolichospermum and microcystin production in Detroit Lake (Oregon, USA).Harmful algae · 2025Article
- Quorum sensing in biofilm-mediated heavy metal resistance and transformation: environmental perspectives and bioremediation.Frontiers in microbiology · 2025Review
- Insights into the role of cyclopropane fatty acid synthase (CfaS) from extreme acidophile in bacterial defense against environmental acid stress.Extremophiles : life under extreme conditions · 2024Article
- Methods for studying microbial acid stress responses: from molecules to populations.FEMS microbiology reviews · 2024Review
- Omics technology draws a comprehensive heavy metal resistance strategy in bacteria.World journal of microbiology & biotechnology · 2024Review
- Molecular docking, molecular dynamics simulations and binding free energy studies of interactions between Mycobacterium tuberculosis Pks13, PknG and bioactive constituents of extremophilic bacteria.Scientific reports · 2024Article
- Genomic analysis of acid tolerance genes and deciphering the function ofFrontiers in microbiology · 2024Article
- Mechanisms of bioleaching: iron and sulfur oxidation by acidophilic microorganisms.Essays in biochemistry · 2023Review
- Comparative genomics reveals intraspecific divergence ofMicrobial genomics · 2023Article
- ONature communications · 2023Article
- ComammoxApplied and environmental microbiology · 2023Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microbial communities in acid mine drainage have been extensively studied to reveal their roles in acid generation and adaption to this environment. Lacking, however, are integrated community- and organism-wide comparative gene transcriptional analyses that could reveal the response and adaptation mechanisms of these extraordinary microorganisms to different environmental conditions. In this study, comparative metagenomics and metatranscriptomics were performed on microbial assemblages collected from four geochemically distinct acid mine drainage (AMD) sites. Taxonomic analysis uncovered unexpectedly high microbial biodiversity of these extremely acidophilic communities, and the abundant taxa of Acidithiobacillus, Leptospirillum and Acidiphilium exhibited high transcriptional activities. Community-wide comparative analyses clearly showed that the AMD microorganisms adapted to the different environmental conditions via regulating the expression of genes involved in multiple in situ functional activities, including low-pH adaptation, carbon, nitrogen and phosphate assimilation, energy generation, environmental stress resistance, and other functions. Organism-wide comparative analyses of the active taxa revealed environment-dependent gene transcriptional profiles, especially the distinct strategies used by Acidithiobacillus ferrivorans and Leptospirillum ferrodiazotrophum in nutrients assimilation and energy generation for survival under different conditions. Overall, these findings demonstrate that the gene transcriptional profiles of AMD microorganisms are closely related to the site physiochemical characteristics, providing clues into the microbial response and adaptation mechanisms in the oligotrophic, extremely acidic environments.
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