SynthesisThe ISME journal2015
Relationships between protein-encoding gene abundance and corresponding process are commonly assumed yet rarely observed.
Synthesis in The ISME journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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Who cites it
100 citing papers in PubMed, 358 citations in OpenAlex.
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- Microbial physiological trait shifts link heavy metal remediation to enhanced soil carbon storage potential.The ISME journal · 2026Article
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- Functional diversity of soil microbial communities increases with ecosystem development.Nature communications · 2025Article
- Genome-wide identification and characterization of BAHD acyltransferases in black pepper (Piper nigrum L.) reveals their important role in piperine biosynthesis.Scientific reports · 2025Article
- Spatio-Temporal Resolution of Microbial Functions and Taxa Associated With Cyanobacterial Harmful Algae Blooms Along a 500-Km Aquatic Continuum in the Lake Erie Watershed.Environmental microbiology · 2025Article
- Wildfire-Induced Losses of Soil Particulate and Mineral-Associated Organic Carbon Persist for Over 4 Years in a Chaparral Ecosystem.Global change biology · 2025Article
- Exploring sub-species variation in food microbiomes: a roadmap to reveal hidden diversity and functional potential.Applied and environmental microbiology · 2025Review
- Decoupling of bacterial production and respiration in the surface water of the North Pacific Subtropical Gyre.Marine life science & technology · 2025Article
- Circadian Control of Protein Synthesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Nitrogen Availability and Changes in Precipitation Alter Microbially Mediated NO and NGlobal change biology · 2025Article
- Metaproteomic analysis decodes trophic interactions of microorganisms in the dark ocean.Nature communications · 2024Article
- Genomic fingerprints of the world's soil ecosystems.mSystems · 2024Article
- Substrate uptake patterns shape niche separation in marine prokaryotic microbiome.Science advances · 2024Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For any enzyme-catalyzed reaction to occur, the corresponding protein-encoding genes and transcripts are necessary prerequisites. Thus, a positive relationship between the abundance of gene or transcripts and corresponding process rates is often assumed. To test this assumption, we conducted a meta-analysis of the relationships between gene and/or transcript abundances and corresponding process rates. We identified 415 studies that quantified the abundance of genes or transcripts for enzymes involved in carbon or nitrogen cycling. However, in only 59 of these manuscripts did the authors report both gene or transcript abundance and rates of the appropriate process. We found that within studies there was a significant but weak positive relationship between gene abundance and the corresponding process. Correlations were not strengthened by accounting for habitat type, differences among genes or reaction products versus reactants, suggesting that other ecological and methodological factors may affect the strength of this relationship. Our findings highlight the need for fundamental research on the factors that control transcription, translation and enzyme function in natural systems to better link genomic and transcriptomic data to ecosystem processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.