Evidence map›Paper›PMID 25535916›Full record

ArticleDevelopmental cell2014

Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.

Tae-Yeon Eom, Amelia Stanco, Jiami Guo, Gary Wilkins, Danielle Deslauriers, Jessica Yan, Chase Monckton, Joshua Blair, Eesim Oon, Abby Perez and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. APC in the nervous system.Medical molecular morphology · 2026
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  15. Microtubule plus-end tracking proteins in neuronal development.Cellular and molecular life sciences : CMLS · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Tae-Yeon EomUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Amelia StancoDepartment of Psychiatry, Neuroscience Program, and Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, San Francisco, CA 94158-2324, USA.
Jiami GuoUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Gary WilkinsUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Danielle DeslauriersUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Jessica YanUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Chase MoncktonUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Joshua BlairUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Eesim OonUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Abby PerezUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Eduardo SalasUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Adrianna OhUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Vladimir GhukasyanUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
William D SniderUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
John L R RubensteinDepartment of Psychiatry, Neuroscience Program, and Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, San Francisco, CA 94158-2324, USA.
E S AntonUNC Neuroscience Center and Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: anton@med.unc.edu.
University of North Carolina at Chapel Hill · USUniversity of California, San Francisco · US

Funding

UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5M
Preclinical CoreU54HD079124 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PIVEN, JOSEPH · 2013 to 2019
$8.0M
ROLE OF GGF IN RADIAL GLIAL CELL DEVELOPMENTR01MH060929 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON, EVA S · 2000 to 2019
$5.7M
NICHD NIH HHS U54 HD079124NIMH NIH HHS MH060929NIMH NIH HHS R01 MH060929NINDS NIH HHS P30 NS045892
6 · The paper itself

Abstract

Coordinated migration of distinct classes of neurons to appropriate positions leads to the formation of functional neuronal circuitry in the cerebral cortex. The two major classes of cortical neurons, interneurons and projection neurons, utilize distinctly different modes (radial versus tangential) and routes of migration to arrive at their final positions in the cerebral cortex. Here, we show that adenomatous polyposis coli (APC) modulates microtubule (MT) severing in interneurons to facilitate tangential mode of interneuron migration, but not the glial-guided, radial migration of projection neurons. APC regulates the stability and activity of the MT-severing protein p60-katanin in interneurons to promote the rapid remodeling of neuronal processes necessary for interneuron migration. These findings reveal how severing and restructuring of MTs facilitate distinct modes of neuronal migration necessary for laminar organization of neurons in the developing cerebral cortex.

Indexed as

Gene Expression Regulation, DevelopmentalAdenosine TriphosphatasesAllelesAnimalsApc1 Subunit, Anaphase-Promoting Complex-CyclosomeCell DifferentiationCell MovementCerebral CortexCytoskeletonGene DeletionGreen Fluorescent ProteinsInterneuronsKataninMiceMice, TransgenicMicroscopy, FluorescenceAdenosine TriphosphatasesAnapc1 protein, mouseApc1 Subunit, Anaphase-Promoting Complex-CyclosomeGreen Fluorescent ProteinsKataninKatna1 protein, mouse

Identifiers

PMID25535916
PMCPMC4289145
OpenAlexW2012783472

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.